ISA Create Mode example

Abstract:

In this notebook, we’ll show how to generate an ISA-Tab and an ISA JSON representation of a metabolomics study. The study uses GC-MS and 13C NMR on 3 distinct sample types (liver, blood and heart) collected from study subjects assigned to 3 distinct study arms.

GC-MS acquisition were carried out in duplicate, extracts were derivatized using BSA and acquired on an Agilent QTOF in both positive and negative modes. 13C NMR free induction decays were acquired on a Bruker Avance, using CPMG and PSEQ pulse sequences in duplicates.

1. Loading ISA-API model and relevant library

# If executing the notebooks on `Google Colab`,uncomment the following command 
# and run it to install the required python libraries. Also, make the test datasets available.

# !pip install -r requirements.txt
from isatools import isatab
from isatools.isajson import ISAJSONEncoder
from collections import OrderedDict
from isatools.model import (
    Investigation,
    OntologyAnnotation,
    FactorValue,
    Characteristic
)
from isatools.create.model import (
    Treatment,
    NonTreatment,
    StudyCell,
    StudyArm,
    ProductNode,
    SampleAndAssayPlan,
    StudyDesign,
    QualityControl
)
from isatools.create.constants import (
    BASE_FACTORS,
    SCREEN,
    RUN_IN,
    WASHOUT,
    FOLLOW_UP,
    SAMPLE,
    EXTRACT,
    LABELED_EXTRACT,
    DATA_FILE
)
from isatools.isatab import dump_tables_to_dataframes as dumpdf
import os
import json

2. Setting variables:

NAME = 'name'
FACTORS_0_VALUE = OntologyAnnotation(term='nitroglycerin')
FACTORS_0_VALUE_ALT = OntologyAnnotation(term='alcohol')
FACTORS_0_VALUE_THIRD = OntologyAnnotation(term='water')

FACTORS_1_VALUE = 5
FACTORS_1_UNIT = OntologyAnnotation(term='kg/m^3')

FACTORS_2_VALUE = 100.0
FACTORS_2_VALUE_ALT = 50.0
FACTORS_2_UNIT = OntologyAnnotation(term='s')

TEST_EPOCH_0_NAME = 'test epoch 0'
TEST_EPOCH_1_NAME = 'test epoch 1'
TEST_EPOCH_2_NAME = 'test epoch 2'

TEST_STUDY_ARM_NAME_00 = 'test arm'
TEST_STUDY_ARM_NAME_01 = 'another arm'
TEST_STUDY_ARM_NAME_02 = 'yet another arm'

TEST_STUDY_DESIGN_NAME = 'test study design'

TEST_EPOCH_0_RANK = 0

SCREEN_DURATION_VALUE = 100
FOLLOW_UP_DURATION_VALUE = 5*366
WASHOUT_DURATION_VALUE = 30
DURATION_UNIT = OntologyAnnotation(term='day')

3. Declaration of ISA Sample / Biomaterial templates for liver, blood and heart

sample_list = [
        {
            'node_type': SAMPLE,
            'characteristics_category': OntologyAnnotation(term='organism part'),
            'characteristics_value': OntologyAnnotation(term='liver'),
            'size': 1,
            'technical_replicates': None,
            'is_input_to_next_protocols': True
        },
        {
            'node_type': SAMPLE,
            'characteristics_category': OntologyAnnotation(term='organism part'),
            'characteristics_value': OntologyAnnotation(term='blood'),
            'size': 1,
            'technical_replicates': None,
            'is_input_to_next_protocols': True
        },
        {
            'node_type': SAMPLE,
            'characteristics_category': OntologyAnnotation(term='organism part'),
            'characteristics_value': OntologyAnnotation(term='heart'),
            'size': 1,
            'technical_replicates': None,
            'is_input_to_next_protocols': True
        }
]

4. Declaration of ISA Assay templates as Python OrderedDict

# A Mass Spectrometry based metabolite profiling assay

ms_assay_dict = OrderedDict([
    ('measurement_type', OntologyAnnotation(term='metabolite profiling')),
    ('technology_type', OntologyAnnotation(term='mass spectrometry')),
    ('extraction', {}),
    ('extract', [
        {
            'node_type': EXTRACT,
            'characteristics_category': OntologyAnnotation(term='extract type'),
            'characteristics_value': OntologyAnnotation(term='polar fraction'),
            'size': 1,
            'is_input_to_next_protocols': True
        },
        {
            'node_type': EXTRACT,
            'characteristics_category': OntologyAnnotation(term='extract type'),
            'characteristics_value': OntologyAnnotation(term='lipids'),
            'size': 1,
            'is_input_to_next_protocols': True
        }
    ]),
    ('derivatization', {
        '#replicates': 1,
        OntologyAnnotation(term='derivatization'): ['sylalation'],
        OntologyAnnotation(term='derivatization'): ['bis(trimethylsilyl)acetamide'],
    }),
    ('labeled extract', [
        {
            'node_type': LABELED_EXTRACT,
            'characteristics_category': OntologyAnnotation(term='labeled extract type'),
            'characteristics_value': '',
            'size': 1,
            'is_input_to_next_protocols': True
        }
    ]),
    ('mass spectrometry', {
        '#replicates': 2,
        OntologyAnnotation(term='instrument'): ['Agilent QTOF'],
        OntologyAnnotation(term='injection_mode'): ['GC'],
        OntologyAnnotation(term='acquisition_mode'): ['positive mode','negative mode']
    }),
    ('raw spectral data file', [
        {
            'node_type': DATA_FILE,
            'size': 1,
            'is_input_to_next_protocols': False
        }
    ])
])


# A high-throughput phenotyping imaging based phenotyping assay

phti_assay_dict = OrderedDict([
    ('measurement_type', OntologyAnnotation(term='phenotyping')),
    ('technology_type', OntologyAnnotation(term='high-throughput imaging')),
            ('extraction', {}),
            ('extract', [
                {
                    'node_type': EXTRACT,
                    'characteristics_category': OntologyAnnotation(term='extract type'),
                    'characteristics_value': OntologyAnnotation(term='supernatant'),
                    'size': 1,
                    'technical_replicates': None,
                    'is_input_to_next_protocols': True
                },
                {
                    'node_type': EXTRACT,
                    'characteristics_category': OntologyAnnotation(term='extract type'),
                    'characteristics_value': OntologyAnnotation(term='pellet'),
                    'size': 1,
                    'technical_replicates': None,
                    'is_input_to_next_protocols': True
                }
            ]),
            ('phenotyping by high throughput imaging', {
                'OntologyAnnotation(term=instrument)': ['lemnatech gigant'],
                'OntologyAnnotation(term=acquisition_mode)': ['UV light','near-IR light','far-IR light','visible light'],
                'OntologyAnnotation(term=camera position)': ['top','120 degree','240 degree','360 degree'],
                'OntologyAnnotation(term=imaging daily schedule)': ['06.00','19.00']
            }),
            ('raw_spectral_data_file', [
                {
                    'node_type': DATA_FILE,
                    'size': 1,
                    'technical_replicates': 2,
                    'is_input_to_next_protocols': False
                }
            ])
        ])

# A liquid chromatography diode-array based metabolite profiling assay

lcdad_assay_dict = OrderedDict([
    ('measurement_type', OntologyAnnotation(term='metabolite identification')),
    ('technology_type', OntologyAnnotation(term='liquid chromatography diode-array detector')),
            ('extraction', {}),
            ('extract', [
                {
                    'node_type': EXTRACT,
                    'characteristics_category': OntologyAnnotation(term='extract type'),
                    'characteristics_value': OntologyAnnotation(term='supernatant'),
                    'size': 1,
                    'technical_replicates': None,
                    'is_input_to_next_protocols': True
                },
                {
                    'node_type': EXTRACT,
                    'characteristics_category': OntologyAnnotation(term='extract type'),
                    'characteristics_value': OntologyAnnotation(term='pellet'),
                    'size': 1,
                    'technical_replicates': None,
                    'is_input_to_next_protocols': True
                }
            ]),
            ('lcdad_spectroscopy', {
                'OntologyAnnotation(term=instrument)': ['Shimadzu DAD 400'],
            }),
            ('raw_spectral_data_file', [
                {
                    'node_type': DATA_FILE,
                    'size': 1,
                    'technical_replicates': 2,
                    'is_input_to_next_protocols': False
                }
            ])
        ])


# A NMR spectroscopy based metabolite profiling assay:
nmr_assay_dict = OrderedDict([
    ('measurement_type', OntologyAnnotation(term='metabolite profiling')),
    ('technology_type', OntologyAnnotation(term='nmr spectroscopy')),
            ('extraction', {}),
            ('extract', [
                {
                    'node_type': EXTRACT,
                    'characteristics_category':  OntologyAnnotation(term='extract type'),
                    'characteristics_value': OntologyAnnotation(term='supernatant'),
                    'size': 1,
                    'technical_replicates': None,
                    'is_input_to_next_protocols': True
                },
                {
                    'node_type': EXTRACT,
                    'characteristics_category':  OntologyAnnotation(term='extract type'),
                    'characteristics_value': OntologyAnnotation(term='pellet'),
                    'size': 1,
                    'technical_replicates': None,
                    'is_input_to_next_protocols': True
                }
            ]),
            ('nmr spectroscopy', {
                OntologyAnnotation(term='instrument'): [OntologyAnnotation(term='Bruker AvanceII 1 GHz')],
                OntologyAnnotation(term='acquisition_mode'): [OntologyAnnotation(term='1D 13C NMR')],
                OntologyAnnotation(term='pulse_sequence'): [OntologyAnnotation(term='CPMG')]
            }),
            ('raw_spectral_data_file', [
                {
                    'node_type': DATA_FILE,
                    'size': 1,
                    'technical_replicates': 1,
                    'is_input_to_next_protocols': False
                }
            ])
    ])

5. Declaring Study Design key elements in terms of Treatments and Non-Treatment elements, Study Cell & Arms

first_treatment = Treatment(factor_values=(
    FactorValue(factor_name=BASE_FACTORS[0], value=FACTORS_0_VALUE),
    FactorValue(factor_name=BASE_FACTORS[1], value=FACTORS_1_VALUE, unit=FACTORS_1_UNIT),
    FactorValue(factor_name=BASE_FACTORS[2], value=FACTORS_2_VALUE, unit=FACTORS_2_UNIT)
))
second_treatment = Treatment(factor_values=(
    FactorValue(factor_name=BASE_FACTORS[0], value=FACTORS_0_VALUE_ALT),
    FactorValue(factor_name=BASE_FACTORS[1], value=FACTORS_1_VALUE, unit=FACTORS_1_UNIT),
    FactorValue(factor_name=BASE_FACTORS[2], value=FACTORS_2_VALUE, unit=FACTORS_2_UNIT)
))
third_treatment = Treatment(factor_values=(
    FactorValue(factor_name=BASE_FACTORS[0], value=FACTORS_0_VALUE_ALT),
    FactorValue(factor_name=BASE_FACTORS[1], value=FACTORS_1_VALUE, unit=FACTORS_1_UNIT),
    FactorValue(factor_name=BASE_FACTORS[2], value=FACTORS_2_VALUE_ALT, unit=FACTORS_2_UNIT)
))
fourth_treatment = Treatment(factor_values=(
    FactorValue(factor_name=BASE_FACTORS[0], value=FACTORS_0_VALUE_THIRD),
    FactorValue(factor_name=BASE_FACTORS[1], value=FACTORS_1_VALUE, unit=FACTORS_1_UNIT),
    FactorValue(factor_name=BASE_FACTORS[2], value=FACTORS_2_VALUE, unit=FACTORS_2_UNIT)
))
screen = NonTreatment(element_type=SCREEN, duration_value=SCREEN_DURATION_VALUE, duration_unit=DURATION_UNIT)
run_in = NonTreatment(element_type=RUN_IN, duration_value=WASHOUT_DURATION_VALUE, duration_unit=DURATION_UNIT)
washout = NonTreatment(element_type=WASHOUT, duration_value=WASHOUT_DURATION_VALUE, duration_unit=DURATION_UNIT)
follow_up = NonTreatment(element_type=FOLLOW_UP, duration_value=FOLLOW_UP_DURATION_VALUE, duration_unit=DURATION_UNIT)
potential_concomitant_washout = NonTreatment(element_type=WASHOUT, duration_value=FACTORS_2_VALUE,
                                                          duration_unit=FACTORS_2_UNIT)
cell_screen = StudyCell(SCREEN, elements=(screen,))
cell_run_in = StudyCell(RUN_IN, elements=(run_in,))
cell_other_run_in = StudyCell('OTHER RUN-IN', elements=(run_in,))
cell_screen_and_run_in = StudyCell('SCREEN AND RUN-IN', elements=[screen, run_in])
cell_concomitant_treatments = StudyCell('CONCOMITANT TREATMENTS',
                                                     elements=([{second_treatment, fourth_treatment}]))
cell_washout_00 = StudyCell(WASHOUT, elements=(washout,))
cell_washout_01 = StudyCell('ANOTHER WASHOUT', elements=(washout,))
cell_single_treatment_00 = StudyCell('SINGLE TREATMENT FIRST', elements=[first_treatment])
cell_single_treatment_01 = StudyCell('SINGLE TREATMENT SECOND', elements=[second_treatment])
cell_single_treatment_02 = StudyCell('SINGLE TREATMENT THIRD', elements=[third_treatment])
cell_multi_elements = StudyCell('MULTI ELEMENTS',
                                             elements=[{first_treatment, second_treatment,
                                                        fourth_treatment}, washout, second_treatment])
cell_multi_elements_padded = StudyCell('MULTI ELEMENTS PADDED',
                                                    elements=[first_treatment, washout, {
                                                        second_treatment,
                                                        fourth_treatment
                                                    }, washout, third_treatment, washout])
cell_follow_up = StudyCell(FOLLOW_UP, elements=(follow_up,))
cell_follow_up_01 = StudyCell('ANOTHER FOLLOW_UP', elements=(follow_up,))
qc = QualityControl()

ms_sample_assay_plan = SampleAndAssayPlan.from_sample_and_assay_plan_dict("ms_sap", sample_list, ms_assay_dict)
nmr_sample_assay_plan = SampleAndAssayPlan.from_sample_and_assay_plan_dict("nmr_sap", sample_list, nmr_assay_dict)

first_arm = StudyArm(name=TEST_STUDY_ARM_NAME_00, group_size=3, arm_map=OrderedDict([
    (cell_screen, None), (cell_run_in, None),
    (cell_single_treatment_00, ms_sample_assay_plan),
    (cell_follow_up, ms_sample_assay_plan)
]))
second_arm = StudyArm(name=TEST_STUDY_ARM_NAME_01, group_size=5, arm_map=OrderedDict([
    (cell_screen, None), (cell_run_in, None),
    (cell_multi_elements, ms_sample_assay_plan),
    (cell_follow_up, ms_sample_assay_plan)
]))
third_arm = StudyArm(name=TEST_STUDY_ARM_NAME_02, group_size=3, arm_map=OrderedDict([
    (cell_screen, None), (cell_run_in, None),
    (cell_multi_elements_padded, ms_sample_assay_plan),
    (cell_follow_up, ms_sample_assay_plan)
]))
third_arm_no_run_in = StudyArm(name=TEST_STUDY_ARM_NAME_02, group_size=3, arm_map=OrderedDict([
    (cell_screen, None),
    (cell_multi_elements_padded, ms_sample_assay_plan),
    (cell_follow_up, ms_sample_assay_plan)
]))
arm_same_name_as_third = StudyArm(name=TEST_STUDY_ARM_NAME_02, group_size=5, arm_map=OrderedDict([
    (cell_screen, None), (cell_run_in, None),
    (cell_single_treatment_01, ms_sample_assay_plan),
    (cell_follow_up, ms_sample_assay_plan)
]))
        # Sample QC (for mass spectroscopy and other)
pre_run_sample_type = ProductNode(
    id_='pre/00', node_type=SAMPLE, name='water', size=2, characteristics=(
        Characteristic(category='dilution', value=10, unit='mg/L'),
    )
)
post_run_sample_type = ProductNode(
    id_='post/00', node_type=SAMPLE, name='ethanol', size=2, characteristics=(
        Characteristic(category='dilution', value=1000, unit='mg/L'),
        Characteristic(category='dilution', value=100, unit='mg/L'),
        Characteristic(category='dilution', value=10, unit='mg/L'),
        Characteristic(category='dilution', value=1, unit='mg/L'),
        Characteristic(category='dilution', value=0.1, unit='mg/L')
    ))
dummy_sample_type = ProductNode(id_='dummy/01', node_type=SAMPLE, name='dummy')
more_dummy_sample_type = ProductNode(id_='dummy/02', node_type=SAMPLE, name='more dummy')
interspersed_sample_types = [(dummy_sample_type, 20)]
qc = QualityControl(
    interspersed_sample_type=interspersed_sample_types,
    pre_run_sample_type=pre_run_sample_type,
    post_run_sample_type=post_run_sample_type
)
single_arm = StudyArm(name=TEST_STUDY_ARM_NAME_00, group_size=10, arm_map=OrderedDict([
    (cell_screen, ms_sample_assay_plan), (cell_run_in,ms_sample_assay_plan),
    (cell_single_treatment_00, nmr_sample_assay_plan),
    (cell_follow_up, nmr_sample_assay_plan)
]))
study_design = StudyDesign(study_arms=(single_arm,))

6. Generated ISA Study from ISA Study Design Object

study = study_design.generate_isa_study()
study
isatools.model.Study(filename='s_study_01.txt', identifier='s_01', title='Study Design', description='None', submission_date='', public_release_date='', contacts=[], design_descriptors=[], publications=[], factors=[isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[])], protocols=[isatools.model.Protocol(name='sample collection', protocol_type=isatools.model.OntologyAnnotation(term='sample_collection', term_source=None, term_accession='', comments=[]), uri='', version='', parameters=[isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='Sampling order', term_source=None, term_accession='', comments=[]), comments=[]), isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='Study cell', term_source=None, term_accession='', comments=[]), comments=[])], components=[], comments=[]), isatools.create.model.ProtocolNode(id=derivatization_000_000, name=assay0 - derivatization, protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), uri=, description=, version=, parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])]), isatools.create.model.ProtocolNode(id=mass_spectrometry_000_001, name=assay0 - mass spectrometry, protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), uri=, description=, version=, parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])]), isatools.create.model.ProtocolNode(id=mass_spectrometry_001_001, name=assay0 - mass spectrometry, protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), uri=, description=, version=, parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])]), isatools.create.model.ProtocolNode(id=nmr_spectroscopy_000_000, name=assay0 - nmr spectroscopy, protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), uri=, description=, version=, parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])]), isatools.create.model.ProtocolNode(id=derivatization_000_001, name=assay0 - derivatization, protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), uri=, description=, version=, parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])]), isatools.create.model.ProtocolNode(id=mass_spectrometry_001_000, name=assay0 - mass spectrometry, protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), uri=, description=, version=, parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])]), isatools.create.model.ProtocolNode(id=mass_spectrometry_000_000, name=assay0 - mass spectrometry, protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), uri=, description=, version=, parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])]), isatools.create.model.ProtocolNode(id=nmr_spectroscopy_000_001, name=assay0 - nmr spectroscopy, protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), uri=, description=, version=, parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])]), isatools.create.model.ProtocolNode(id=extraction_000, name=assay0 - extraction, protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
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isatools.model.RawDataFile(filename='AT0-S57-raw_spectral_data_file-R2-', generated_from=[], comments=[]), isatools.model.RawDataFile(filename='AT0-S58-raw_spectral_data_file-R1-', generated_from=[], comments=[]), isatools.model.RawDataFile(filename='AT0-S58-raw_spectral_data_file-R2-', generated_from=[], comments=[]), isatools.model.RawDataFile(filename='AT0-S59-raw_spectral_data_file-R1-', generated_from=[], comments=[]), isatools.model.RawDataFile(filename='AT0-S59-raw_spectral_data_file-R2-', generated_from=[], comments=[]), isatools.model.RawDataFile(filename='AT0-S60-raw_spectral_data_file-R1-', generated_from=[], comments=[]), isatools.model.RawDataFile(filename='AT0-S60-raw_spectral_data_file-R2-', generated_from=[], comments=[])], samples=[], process_sequence=[isatools.model.Process(id="". name="AT0-S1-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ02_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S1-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S1-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S1-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
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    term_accession=
    comments=0 Comment objects
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        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S1-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S1-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S1-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
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        uri=, 
        description=, 
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        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S1-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S1-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S2-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
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), 
        uri=, 
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        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ09_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S2-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S2-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S2-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S2-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S2-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S2-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S2-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S2-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S3-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ03_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S3-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S3-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S3-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S3-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S3-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S3-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S3-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S3-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S4-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ04_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S4-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S4-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S4-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S4-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S4-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S4-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S4-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S4-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S5-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ07_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S5-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S5-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S5-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S5-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S5-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S5-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S5-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S5-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S6-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ08_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S6-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S6-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S6-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S6-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S6-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S6-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S6-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S6-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S7-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ10_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S7-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S7-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S7-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S7-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S7-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S7-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S7-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S7-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S8-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ01_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S8-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S8-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S8-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S8-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S8-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S8-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S8-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S8-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S9-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ06_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S9-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S9-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S9-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S9-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S9-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S9-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S9-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S9-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S10-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ05_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S10-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S10-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S10-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S10-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S10-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S10-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S10-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S10-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S11-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ02_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S11-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S11-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S11-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S11-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S11-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S11-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S11-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S11-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S12-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ09_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S12-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S12-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S12-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S12-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S12-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S12-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S12-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S12-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S13-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ03_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S13-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S13-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S13-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S13-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S13-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S13-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S13-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S13-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S14-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ04_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S14-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S14-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S14-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S14-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S14-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S14-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S14-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S14-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S15-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ07_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S15-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S15-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S15-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S15-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S15-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S15-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S15-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S15-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S16-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ08_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S16-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S16-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S16-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S16-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S16-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S16-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S16-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S16-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S17-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ10_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S17-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S17-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S17-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S17-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S17-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S17-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S17-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S17-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S18-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ01_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S18-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S18-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S18-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S18-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S18-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S18-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S18-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S18-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S19-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ06_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S19-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S19-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S19-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S19-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S19-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S19-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S19-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S19-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S20-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ05_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S20-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S20-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S20-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S20-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S20-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S20-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S20-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S20-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S21-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ02_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S21-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S21-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S21-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S21-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S21-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S21-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S21-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S21-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S22-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ09_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S22-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S22-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S22-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S22-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S22-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S22-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S22-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S22-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S23-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ03_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S23-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S23-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S23-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S23-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S23-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S23-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S23-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S23-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S24-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ04_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S24-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S24-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S24-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S24-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S24-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S24-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S24-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S24-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S25-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ07_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S25-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S25-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S25-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S25-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S25-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S25-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S25-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S25-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S26-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ08_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S26-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S26-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S26-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S26-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S26-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S26-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S26-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S26-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S27-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ10_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S27-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S27-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S27-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S27-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S27-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S27-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S27-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S27-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S28-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ01_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S28-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S28-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S28-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S28-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S28-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S28-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S28-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S28-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S29-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ06_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S29-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S29-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S29-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S29-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S29-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S29-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S29-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S29-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S30-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ05_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S30-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S30-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S30-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S30-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S30-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S30-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S30-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S30-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S31-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ02_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S31-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S31-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S31-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S31-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S31-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S31-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S31-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S31-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S32-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ09_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S32-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S32-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S32-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S32-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S32-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S32-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S32-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S32-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S33-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ03_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S33-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S33-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S33-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S33-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S33-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S33-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S33-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S33-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S34-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ04_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S34-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S34-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S34-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S34-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S34-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S34-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S34-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S34-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S35-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ07_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S35-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S35-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S35-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S35-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S35-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S35-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S35-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S35-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S36-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ08_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S36-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S36-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S36-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S36-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S36-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S36-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S36-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S36-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S37-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ10_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S37-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S37-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S37-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S37-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S37-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S37-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S37-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S37-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S38-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ01_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S38-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S38-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S38-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S38-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S38-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S38-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S38-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S38-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S39-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ06_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S39-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S39-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S39-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S39-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S39-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S39-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S39-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S39-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S40-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ05_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S40-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S40-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S40-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S40-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S40-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S40-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S40-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S40-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S41-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ02_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S41-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S41-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S41-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S41-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S41-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S41-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S41-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S41-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S42-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ09_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S42-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S42-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S42-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S42-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S42-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S42-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S42-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S42-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S43-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ03_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S43-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S43-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S43-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S43-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S43-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S43-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S43-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S43-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S44-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ04_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S44-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S44-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S44-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S44-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S44-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S44-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S44-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S44-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S45-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ07_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S45-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S45-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S45-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S45-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S45-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S45-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S45-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S45-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S46-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ08_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S46-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S46-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S46-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S46-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S46-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S46-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S46-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S46-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S47-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ10_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S47-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S47-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S47-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S47-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S47-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S47-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S47-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S47-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S48-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ01_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S48-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S48-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S48-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S48-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S48-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S48-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S48-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S48-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S49-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ06_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S49-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S49-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S49-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S49-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S49-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S49-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S49-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S49-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S50-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ05_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S50-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S50-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S50-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S50-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S50-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S50-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S50-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S50-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S51-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ02_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S51-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S51-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S51-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S51-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S51-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S51-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S51-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S51-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S52-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ09_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S52-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S52-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S52-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S52-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S52-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S52-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S52-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S52-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S53-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ03_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S53-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S53-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S53-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S53-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S53-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S53-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S53-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S53-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S54-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ04_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S54-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S54-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S54-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S54-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S54-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S54-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S54-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S54-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S55-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ07_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S55-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S55-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S55-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S55-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S55-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S55-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S55-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S55-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S56-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ08_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S56-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S56-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S56-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S56-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S56-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S56-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S56-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S56-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S57-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ10_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S57-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S57-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S57-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S57-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S57-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S57-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S57-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S57-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S58-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ01_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S58-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S58-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S58-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S58-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S58-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S58-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S58-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S58-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S59-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ06_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S59-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S59-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S59-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S59-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S59-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S59-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S59-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S59-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S60-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ05_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S60-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S60-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S60-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
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        uri=, 
        description=, 
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        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S60-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S60-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S60-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
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        uri=, 
        description=, 
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        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
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generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S59-raw-spectral-data-file-R6', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S59-raw-spectral-data-file-R7', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S59-raw-spectral-data-file-R8', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R1', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R2', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R3', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R4', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R5', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R6', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R7', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R8', generated_from=[], comments=[])], samples=[], process_sequence=[isatools.model.Process(id="". name="AT0-S1-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ02_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S1-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S1-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S1-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S1-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S1-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S1-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S1-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S1-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S1-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S1-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S1-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S1-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S1-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S1-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S1-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S1-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S1-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S1-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S1-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S1-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S1-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S1-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S1-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S1-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S1-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S1-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S1-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S1-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S1-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S1-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S1-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S1-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S2-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ09_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S2-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S2-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S2-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S2-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S2-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S2-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S2-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S2-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S2-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S2-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S2-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S2-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S2-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S2-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S2-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S2-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S2-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S2-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S2-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S2-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S2-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S2-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S2-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S2-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S2-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S2-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S2-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S2-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S2-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S2-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S2-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S2-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S3-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ03_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S3-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S3-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S3-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S3-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S3-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S3-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S3-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S3-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S3-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S3-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S3-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S3-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S3-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S3-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S3-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S3-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S3-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S3-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S3-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S3-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S3-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S3-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S3-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S3-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S3-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S3-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S3-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S3-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S3-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S3-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S3-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S3-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S4-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ04_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S4-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S4-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S4-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S4-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S4-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S4-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S4-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S4-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S4-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S4-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S4-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S4-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S4-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S4-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S4-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S4-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S4-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S4-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S4-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S4-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S4-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S4-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S4-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S4-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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), 
        uri=, 
        description=, 
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        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S4-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S4-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S4-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S4-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S4-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S4-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S4-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S4-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S5-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ07_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S5-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S5-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S5-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S5-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S5-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S5-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S5-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S5-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S5-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S5-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S5-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S5-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S5-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S5-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S5-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S5-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S5-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S5-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S5-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S5-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S5-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S5-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S5-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S5-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S5-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S5-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S5-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S5-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S5-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S5-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S5-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S5-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S6-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ08_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S6-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S6-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S6-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S6-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S6-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S6-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S6-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S6-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S6-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S6-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S6-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S6-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S6-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S6-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S6-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S6-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S6-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S6-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S6-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S6-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S6-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S6-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S6-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S6-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S6-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S6-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S6-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S6-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S6-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S6-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S6-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S6-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S7-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ10_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S7-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S7-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S7-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S7-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S7-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S7-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S7-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S7-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S7-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S7-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S7-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S7-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S7-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S7-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S7-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S7-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S7-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S7-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S7-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S7-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S7-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S7-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S7-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S7-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S7-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S7-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S7-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S7-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S7-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S7-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S7-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S7-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S8-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ01_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S8-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S8-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S8-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S8-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S8-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S8-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S8-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S8-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S8-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S8-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S8-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S8-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S8-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S8-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S8-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S8-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S8-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S8-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S8-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S8-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S8-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S8-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S8-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S8-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S8-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S8-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S8-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S8-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S8-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S8-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S8-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S8-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S9-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ06_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S9-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S9-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S9-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S9-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S9-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S9-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S9-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S9-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S9-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S9-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S9-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S9-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S9-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S9-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S9-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S9-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S9-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S9-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S9-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S9-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S9-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S9-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S9-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S9-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S9-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S9-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S9-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S9-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S9-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S9-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S9-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S9-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S10-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ05_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S10-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S10-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S10-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S10-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S10-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S10-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S10-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S10-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S10-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S10-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S10-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S10-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S10-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S10-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S10-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S10-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S10-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S10-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S10-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S10-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S10-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S10-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S10-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S10-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S10-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S10-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S10-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S10-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S10-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S10-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S10-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S10-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S11-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ02_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S11-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S11-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S11-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S11-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S11-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S11-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S11-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S11-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S11-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S11-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S11-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S11-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S11-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S11-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S11-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S11-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S11-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S11-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S11-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S11-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S11-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S11-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S11-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S11-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S11-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S11-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S11-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S11-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S11-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S11-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S11-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S11-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S12-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ09_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S12-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S12-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S12-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S12-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S12-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S12-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S12-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S12-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S12-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S12-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S12-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S12-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S12-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S12-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S12-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S12-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S12-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S12-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S12-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S12-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S12-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S12-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S12-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S12-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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), 
        uri=, 
        description=, 
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        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S12-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S12-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S12-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S12-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S12-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S12-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S12-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S12-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S13-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ03_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S13-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S13-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S13-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S13-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S13-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S13-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S13-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S13-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S13-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S13-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S13-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S13-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S13-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S13-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S13-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S13-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S13-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S13-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S13-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S13-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S13-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S13-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S13-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S13-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S13-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S13-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S13-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S13-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S13-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S13-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S13-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S13-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S14-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ04_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S14-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S14-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S14-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S14-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S14-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S14-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S14-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S14-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S14-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S14-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S14-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S14-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S14-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S14-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S14-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S14-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S14-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S14-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S14-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S14-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S14-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S14-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S14-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S14-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S14-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S14-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S14-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S14-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S14-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S14-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S14-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S14-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S15-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ07_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S15-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S15-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S15-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S15-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S15-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S15-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S15-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S15-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S15-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S15-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S15-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S15-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S15-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S15-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S15-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S15-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S15-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S15-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S15-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S15-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S15-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S15-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S15-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S15-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S15-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S15-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S15-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S15-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S15-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S15-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S15-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S15-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S16-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ08_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S16-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S16-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S16-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S16-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S16-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S16-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S16-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S16-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S16-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S16-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S16-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S16-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S16-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S16-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S16-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S16-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S16-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S16-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S16-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S16-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S16-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S16-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S16-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S16-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=&#