ISA Create Mode example¶

Abstract:¶

In this notebook, we’ll show how to generate an ISA-Tab and an ISA JSON representation of a metabolomics study. The study uses GC-MS and 13C NMR on 3 distinct sample types (liver, blood and heart) collected from study subjects assigned to 3 distinct study arms.

GC-MS acquisition were carried out in duplicate, extracts were derivatized using BSA and acquired on an Agilent QTOF in both positive and negative modes. 13C NMR free induction decays were acquired on a Bruker Avance, using CPMG and PSEQ pulse sequences in duplicates.

1. Loading ISA-API model and relevant library¶

# If executing the notebooks on `Google Colab`,uncomment the following command 
# and run it to install the required python libraries. Also, make the test datasets available.

# !pip install -r requirements.txt

from isatools import isatab
from isatools.isajson import ISAJSONEncoder
from collections import OrderedDict
from isatools.model import (
    Investigation,
    OntologyAnnotation,
    FactorValue,
    Characteristic
)
from isatools.create.model import (
    Treatment,
    NonTreatment,
    StudyCell,
    StudyArm,
    ProductNode,
    SampleAndAssayPlan,
    StudyDesign,
    QualityControl
)
from isatools.create.constants import (
    BASE_FACTORS,
    SCREEN,
    RUN_IN,
    WASHOUT,
    FOLLOW_UP,
    SAMPLE,
    EXTRACT,
    LABELED_EXTRACT,
    DATA_FILE
)
from isatools.isatab import dump_tables_to_dataframes as dumpdf
import os
import json

2. Setting variables:¶

NAME = 'name'
FACTORS_0_VALUE = OntologyAnnotation(term='nitroglycerin')
FACTORS_0_VALUE_ALT = OntologyAnnotation(term='alcohol')
FACTORS_0_VALUE_THIRD = OntologyAnnotation(term='water')

FACTORS_1_VALUE = 5
FACTORS_1_UNIT = OntologyAnnotation(term='kg/m^3')

FACTORS_2_VALUE = 100.0
FACTORS_2_VALUE_ALT = 50.0
FACTORS_2_UNIT = OntologyAnnotation(term='s')

TEST_EPOCH_0_NAME = 'test epoch 0'
TEST_EPOCH_1_NAME = 'test epoch 1'
TEST_EPOCH_2_NAME = 'test epoch 2'

TEST_STUDY_ARM_NAME_00 = 'test arm'
TEST_STUDY_ARM_NAME_01 = 'another arm'
TEST_STUDY_ARM_NAME_02 = 'yet another arm'

TEST_STUDY_DESIGN_NAME = 'test study design'

TEST_EPOCH_0_RANK = 0

SCREEN_DURATION_VALUE = 100
FOLLOW_UP_DURATION_VALUE = 5*366
WASHOUT_DURATION_VALUE = 30
DURATION_UNIT = OntologyAnnotation(term='day')

3. Declaration of ISA Sample / Biomaterial templates for liver, blood and heart¶

sample_list = [
        {
            'node_type': SAMPLE,
            'characteristics_category': OntologyAnnotation(term='organism part'),
            'characteristics_value': OntologyAnnotation(term='liver'),
            'size': 1,
            'technical_replicates': None,
            'is_input_to_next_protocols': True
        },
        {
            'node_type': SAMPLE,
            'characteristics_category': OntologyAnnotation(term='organism part'),
            'characteristics_value': OntologyAnnotation(term='blood'),
            'size': 1,
            'technical_replicates': None,
            'is_input_to_next_protocols': True
        },
        {
            'node_type': SAMPLE,
            'characteristics_category': OntologyAnnotation(term='organism part'),
            'characteristics_value': OntologyAnnotation(term='heart'),
            'size': 1,
            'technical_replicates': None,
            'is_input_to_next_protocols': True
        }
]

4. Declaration of ISA Assay templates as Python `OrderedDict`¶

# A Mass Spectrometry based metabolite profiling assay

ms_assay_dict = OrderedDict([
    ('measurement_type', OntologyAnnotation(term='metabolite profiling')),
    ('technology_type', OntologyAnnotation(term='mass spectrometry')),
    ('extraction', {}),
    ('extract', [
        {
            'node_type': EXTRACT,
            'characteristics_category': OntologyAnnotation(term='extract type'),
            'characteristics_value': OntologyAnnotation(term='polar fraction'),
            'size': 1,
            'is_input_to_next_protocols': True
        },
        {
            'node_type': EXTRACT,
            'characteristics_category': OntologyAnnotation(term='extract type'),
            'characteristics_value': OntologyAnnotation(term='lipids'),
            'size': 1,
            'is_input_to_next_protocols': True
        }
    ]),
    ('derivatization', {
        '#replicates': 1,
        OntologyAnnotation(term='derivatization'): ['sylalation'],
        OntologyAnnotation(term='derivatization'): ['bis(trimethylsilyl)acetamide'],
    }),
    ('labeled extract', [
        {
            'node_type': LABELED_EXTRACT,
            'characteristics_category': OntologyAnnotation(term='labeled extract type'),
            'characteristics_value': '',
            'size': 1,
            'is_input_to_next_protocols': True
        }
    ]),
    ('mass spectrometry', {
        '#replicates': 2,
        OntologyAnnotation(term='instrument'): ['Agilent QTOF'],
        OntologyAnnotation(term='injection_mode'): ['GC'],
        OntologyAnnotation(term='acquisition_mode'): ['positive mode','negative mode']
    }),
    ('raw spectral data file', [
        {
            'node_type': DATA_FILE,
            'size': 1,
            'is_input_to_next_protocols': False
        }
    ])
])


# A high-throughput phenotyping imaging based phenotyping assay

phti_assay_dict = OrderedDict([
    ('measurement_type', OntologyAnnotation(term='phenotyping')),
    ('technology_type', OntologyAnnotation(term='high-throughput imaging')),
            ('extraction', {}),
            ('extract', [
                {
                    'node_type': EXTRACT,
                    'characteristics_category': OntologyAnnotation(term='extract type'),
                    'characteristics_value': OntologyAnnotation(term='supernatant'),
                    'size': 1,
                    'technical_replicates': None,
                    'is_input_to_next_protocols': True
                },
                {
                    'node_type': EXTRACT,
                    'characteristics_category': OntologyAnnotation(term='extract type'),
                    'characteristics_value': OntologyAnnotation(term='pellet'),
                    'size': 1,
                    'technical_replicates': None,
                    'is_input_to_next_protocols': True
                }
            ]),
            ('phenotyping by high throughput imaging', {
                'OntologyAnnotation(term=instrument)': ['lemnatech gigant'],
                'OntologyAnnotation(term=acquisition_mode)': ['UV light','near-IR light','far-IR light','visible light'],
                'OntologyAnnotation(term=camera position)': ['top','120 degree','240 degree','360 degree'],
                'OntologyAnnotation(term=imaging daily schedule)': ['06.00','19.00']
            }),
            ('raw_spectral_data_file', [
                {
                    'node_type': DATA_FILE,
                    'size': 1,
                    'technical_replicates': 2,
                    'is_input_to_next_protocols': False
                }
            ])
        ])

# A liquid chromatography diode-array based metabolite profiling assay

lcdad_assay_dict = OrderedDict([
    ('measurement_type', OntologyAnnotation(term='metabolite identification')),
    ('technology_type', OntologyAnnotation(term='liquid chromatography diode-array detector')),
            ('extraction', {}),
            ('extract', [
                {
                    'node_type': EXTRACT,
                    'characteristics_category': OntologyAnnotation(term='extract type'),
                    'characteristics_value': OntologyAnnotation(term='supernatant'),
                    'size': 1,
                    'technical_replicates': None,
                    'is_input_to_next_protocols': True
                },
                {
                    'node_type': EXTRACT,
                    'characteristics_category': OntologyAnnotation(term='extract type'),
                    'characteristics_value': OntologyAnnotation(term='pellet'),
                    'size': 1,
                    'technical_replicates': None,
                    'is_input_to_next_protocols': True
                }
            ]),
            ('lcdad_spectroscopy', {
                'OntologyAnnotation(term=instrument)': ['Shimadzu DAD 400'],
            }),
            ('raw_spectral_data_file', [
                {
                    'node_type': DATA_FILE,
                    'size': 1,
                    'technical_replicates': 2,
                    'is_input_to_next_protocols': False
                }
            ])
        ])


# A NMR spectroscopy based metabolite profiling assay:
nmr_assay_dict = OrderedDict([
    ('measurement_type', OntologyAnnotation(term='metabolite profiling')),
    ('technology_type', OntologyAnnotation(term='nmr spectroscopy')),
            ('extraction', {}),
            ('extract', [
                {
                    'node_type': EXTRACT,
                    'characteristics_category':  OntologyAnnotation(term='extract type'),
                    'characteristics_value': OntologyAnnotation(term='supernatant'),
                    'size': 1,
                    'technical_replicates': None,
                    'is_input_to_next_protocols': True
                },
                {
                    'node_type': EXTRACT,
                    'characteristics_category':  OntologyAnnotation(term='extract type'),
                    'characteristics_value': OntologyAnnotation(term='pellet'),
                    'size': 1,
                    'technical_replicates': None,
                    'is_input_to_next_protocols': True
                }
            ]),
            ('nmr spectroscopy', {
                OntologyAnnotation(term='instrument'): [OntologyAnnotation(term='Bruker AvanceII 1 GHz')],
                OntologyAnnotation(term='acquisition_mode'): [OntologyAnnotation(term='1D 13C NMR')],
                OntologyAnnotation(term='pulse_sequence'): [OntologyAnnotation(term='CPMG')]
            }),
            ('raw_spectral_data_file', [
                {
                    'node_type': DATA_FILE,
                    'size': 1,
                    'technical_replicates': 1,
                    'is_input_to_next_protocols': False
                }
            ])
    ])

5. Declaring Study Design key elements in terms of Treatments and Non-Treatment elements, Study Cell & Arms¶

first_treatment = Treatment(factor_values=(
    FactorValue(factor_name=BASE_FACTORS[0], value=FACTORS_0_VALUE),
    FactorValue(factor_name=BASE_FACTORS[1], value=FACTORS_1_VALUE, unit=FACTORS_1_UNIT),
    FactorValue(factor_name=BASE_FACTORS[2], value=FACTORS_2_VALUE, unit=FACTORS_2_UNIT)
))
second_treatment = Treatment(factor_values=(
    FactorValue(factor_name=BASE_FACTORS[0], value=FACTORS_0_VALUE_ALT),
    FactorValue(factor_name=BASE_FACTORS[1], value=FACTORS_1_VALUE, unit=FACTORS_1_UNIT),
    FactorValue(factor_name=BASE_FACTORS[2], value=FACTORS_2_VALUE, unit=FACTORS_2_UNIT)
))
third_treatment = Treatment(factor_values=(
    FactorValue(factor_name=BASE_FACTORS[0], value=FACTORS_0_VALUE_ALT),
    FactorValue(factor_name=BASE_FACTORS[1], value=FACTORS_1_VALUE, unit=FACTORS_1_UNIT),
    FactorValue(factor_name=BASE_FACTORS[2], value=FACTORS_2_VALUE_ALT, unit=FACTORS_2_UNIT)
))
fourth_treatment = Treatment(factor_values=(
    FactorValue(factor_name=BASE_FACTORS[0], value=FACTORS_0_VALUE_THIRD),
    FactorValue(factor_name=BASE_FACTORS[1], value=FACTORS_1_VALUE, unit=FACTORS_1_UNIT),
    FactorValue(factor_name=BASE_FACTORS[2], value=FACTORS_2_VALUE, unit=FACTORS_2_UNIT)
))
screen = NonTreatment(element_type=SCREEN, duration_value=SCREEN_DURATION_VALUE, duration_unit=DURATION_UNIT)
run_in = NonTreatment(element_type=RUN_IN, duration_value=WASHOUT_DURATION_VALUE, duration_unit=DURATION_UNIT)
washout = NonTreatment(element_type=WASHOUT, duration_value=WASHOUT_DURATION_VALUE, duration_unit=DURATION_UNIT)
follow_up = NonTreatment(element_type=FOLLOW_UP, duration_value=FOLLOW_UP_DURATION_VALUE, duration_unit=DURATION_UNIT)
potential_concomitant_washout = NonTreatment(element_type=WASHOUT, duration_value=FACTORS_2_VALUE,
                                                          duration_unit=FACTORS_2_UNIT)
cell_screen = StudyCell(SCREEN, elements=(screen,))
cell_run_in = StudyCell(RUN_IN, elements=(run_in,))
cell_other_run_in = StudyCell('OTHER RUN-IN', elements=(run_in,))
cell_screen_and_run_in = StudyCell('SCREEN AND RUN-IN', elements=[screen, run_in])
cell_concomitant_treatments = StudyCell('CONCOMITANT TREATMENTS',
                                                     elements=([{second_treatment, fourth_treatment}]))
cell_washout_00 = StudyCell(WASHOUT, elements=(washout,))
cell_washout_01 = StudyCell('ANOTHER WASHOUT', elements=(washout,))
cell_single_treatment_00 = StudyCell('SINGLE TREATMENT FIRST', elements=[first_treatment])
cell_single_treatment_01 = StudyCell('SINGLE TREATMENT SECOND', elements=[second_treatment])
cell_single_treatment_02 = StudyCell('SINGLE TREATMENT THIRD', elements=[third_treatment])
cell_multi_elements = StudyCell('MULTI ELEMENTS',
                                             elements=[{first_treatment, second_treatment,
                                                        fourth_treatment}, washout, second_treatment])
cell_multi_elements_padded = StudyCell('MULTI ELEMENTS PADDED',
                                                    elements=[first_treatment, washout, {
                                                        second_treatment,
                                                        fourth_treatment
                                                    }, washout, third_treatment, washout])
cell_follow_up = StudyCell(FOLLOW_UP, elements=(follow_up,))
cell_follow_up_01 = StudyCell('ANOTHER FOLLOW_UP', elements=(follow_up,))
qc = QualityControl()

ms_sample_assay_plan = SampleAndAssayPlan.from_sample_and_assay_plan_dict("ms_sap", sample_list, ms_assay_dict)
nmr_sample_assay_plan = SampleAndAssayPlan.from_sample_and_assay_plan_dict("nmr_sap", sample_list, nmr_assay_dict)

first_arm = StudyArm(name=TEST_STUDY_ARM_NAME_00, group_size=3, arm_map=OrderedDict([
    (cell_screen, None), (cell_run_in, None),
    (cell_single_treatment_00, ms_sample_assay_plan),
    (cell_follow_up, ms_sample_assay_plan)
]))
second_arm = StudyArm(name=TEST_STUDY_ARM_NAME_01, group_size=5, arm_map=OrderedDict([
    (cell_screen, None), (cell_run_in, None),
    (cell_multi_elements, ms_sample_assay_plan),
    (cell_follow_up, ms_sample_assay_plan)
]))
third_arm = StudyArm(name=TEST_STUDY_ARM_NAME_02, group_size=3, arm_map=OrderedDict([
    (cell_screen, None), (cell_run_in, None),
    (cell_multi_elements_padded, ms_sample_assay_plan),
    (cell_follow_up, ms_sample_assay_plan)
]))
third_arm_no_run_in = StudyArm(name=TEST_STUDY_ARM_NAME_02, group_size=3, arm_map=OrderedDict([
    (cell_screen, None),
    (cell_multi_elements_padded, ms_sample_assay_plan),
    (cell_follow_up, ms_sample_assay_plan)
]))
arm_same_name_as_third = StudyArm(name=TEST_STUDY_ARM_NAME_02, group_size=5, arm_map=OrderedDict([
    (cell_screen, None), (cell_run_in, None),
    (cell_single_treatment_01, ms_sample_assay_plan),
    (cell_follow_up, ms_sample_assay_plan)
]))
        # Sample QC (for mass spectroscopy and other)
pre_run_sample_type = ProductNode(
    id_='pre/00', node_type=SAMPLE, name='water', size=2, characteristics=(
        Characteristic(category='dilution', value=10, unit='mg/L'),
    )
)
post_run_sample_type = ProductNode(
    id_='post/00', node_type=SAMPLE, name='ethanol', size=2, characteristics=(
        Characteristic(category='dilution', value=1000, unit='mg/L'),
        Characteristic(category='dilution', value=100, unit='mg/L'),
        Characteristic(category='dilution', value=10, unit='mg/L'),
        Characteristic(category='dilution', value=1, unit='mg/L'),
        Characteristic(category='dilution', value=0.1, unit='mg/L')
    ))
dummy_sample_type = ProductNode(id_='dummy/01', node_type=SAMPLE, name='dummy')
more_dummy_sample_type = ProductNode(id_='dummy/02', node_type=SAMPLE, name='more dummy')
interspersed_sample_types = [(dummy_sample_type, 20)]
qc = QualityControl(
    interspersed_sample_type=interspersed_sample_types,
    pre_run_sample_type=pre_run_sample_type,
    post_run_sample_type=post_run_sample_type
)

single_arm = StudyArm(name=TEST_STUDY_ARM_NAME_00, group_size=10, arm_map=OrderedDict([
    (cell_screen, ms_sample_assay_plan), (cell_run_in,ms_sample_assay_plan),
    (cell_single_treatment_00, nmr_sample_assay_plan),
    (cell_follow_up, nmr_sample_assay_plan)
]))
study_design = StudyDesign(study_arms=(single_arm,))

6. Generated ISA Study from ISA Study Design Object¶

study = study_design.generate_isa_study()

study

isatools.model.Study(filename='s_study_01.txt', identifier='s_01', title='Study Design', description='None', submission_date='', public_release_date='', contacts=[], design_descriptors=[], publications=[], factors=[isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[])], protocols=[isatools.model.Protocol(name='sample collection', protocol_type=isatools.model.OntologyAnnotation(term='sample_collection', term_source=None, term_accession='', comments=[]), uri='', version='', parameters=[isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='Sampling order', term_source=None, term_accession='', comments=[]), comments=[]), isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='Study cell', term_source=None, term_accession='', comments=[]), comments=[])], components=[], comments=[]), isatools.create.model.ProtocolNode(id=derivatization_000_000, name=assay0 - derivatization, protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), uri=, description=, version=, parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])]), isatools.create.model.ProtocolNode(id=mass_spectrometry_000_001, name=assay0 - mass spectrometry, protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), uri=, description=, version=, parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])]), isatools.create.model.ProtocolNode(id=mass_spectrometry_001_001, name=assay0 - mass spectrometry, protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), uri=, description=, version=, parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])]), isatools.create.model.ProtocolNode(id=nmr_spectroscopy_000_000, name=assay0 - nmr spectroscopy, protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), uri=, description=, version=, parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])]), isatools.create.model.ProtocolNode(id=derivatization_000_001, name=assay0 - derivatization, protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), uri=, description=, version=, parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])]), isatools.create.model.ProtocolNode(id=mass_spectrometry_001_000, name=assay0 - mass spectrometry, protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), uri=, description=, version=, parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])]), isatools.create.model.ProtocolNode(id=mass_spectrometry_000_000, name=assay0 - mass spectrometry, protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), uri=, description=, version=, parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])]), isatools.create.model.ProtocolNode(id=nmr_spectroscopy_000_001, name=assay0 - nmr spectroscopy, protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), uri=, description=, version=, parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])]), isatools.create.model.ProtocolNode(id=extraction_000, name=assay0 - extraction, protocol_type=OntologyAnnotation(
    term=assay0 - extraction
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        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
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    term_accession=
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        uri=, 
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        parameter_values=[])
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        name=assay0 - nmr spectroscopy, 
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        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S1-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S1-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S1-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
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        name=assay0 - nmr spectroscopy, 
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        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ09_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S2-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S2-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S2-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S2-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S2-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S2-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S2-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S2-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S3-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ03_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S3-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S3-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S3-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S3-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S3-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S3-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S3-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S3-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S4-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ04_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S4-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S4-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S4-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S4-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S4-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S4-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S4-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S4-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S5-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ07_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S5-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S5-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S5-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S5-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S5-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S5-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S5-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S5-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S6-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ08_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S6-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S6-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S6-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S6-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S6-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S6-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S6-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S6-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S7-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ10_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S7-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S7-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S7-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S7-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S7-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S7-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S7-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S7-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S8-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ01_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S8-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S8-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S8-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S8-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S8-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S8-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S8-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S8-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S9-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ06_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S9-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S9-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S9-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S9-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S9-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S9-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S9-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S9-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S10-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ05_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S10-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S10-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S10-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S10-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S10-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S10-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S10-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S10-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S11-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ02_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S11-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S11-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S11-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S11-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S11-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S11-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S11-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S11-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S12-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ09_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S12-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S12-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S12-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S12-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S12-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S12-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S12-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S12-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S13-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ03_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S13-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S13-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S13-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S13-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S13-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S13-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S13-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S13-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S14-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ04_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S14-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S14-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S14-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S14-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S14-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S14-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S14-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S14-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S15-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ07_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S15-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S15-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S15-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S15-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S15-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S15-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S15-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S15-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S16-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ08_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S16-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S16-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S16-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S16-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S16-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S16-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S16-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S16-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S17-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ10_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S17-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S17-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S17-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S17-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S17-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S17-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S17-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S17-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S18-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ01_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S18-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S18-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S18-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S18-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S18-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S18-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S18-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S18-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S19-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ06_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S19-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S19-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S19-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S19-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S19-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S19-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S19-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S19-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S20-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ05_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S20-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S20-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S20-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S20-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S20-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S20-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S20-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S20-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S21-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ02_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S21-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S21-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S21-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S21-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S21-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S21-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S21-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S21-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S22-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ09_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S22-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S22-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S22-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S22-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S22-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S22-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S22-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S22-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S23-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ03_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S23-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S23-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S23-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S23-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S23-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S23-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S23-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S23-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S24-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ04_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S24-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S24-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S24-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S24-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S24-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S24-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S24-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S24-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S25-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ07_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S25-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S25-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S25-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S25-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S25-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S25-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S25-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S25-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S26-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ08_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S26-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S26-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S26-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S26-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S26-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S26-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S26-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S26-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S27-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ10_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S27-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S27-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S27-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S27-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S27-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S27-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S27-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S27-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S28-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ01_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S28-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S28-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S28-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S28-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S28-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S28-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S28-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S28-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S29-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ06_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S29-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S29-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S29-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S29-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S29-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S29-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S29-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S29-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S30-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ05_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S30-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S30-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S30-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S30-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S30-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S30-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S30-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S30-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S31-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ02_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S31-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S31-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S31-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S31-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S31-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S31-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S31-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S31-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S32-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ09_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S32-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S32-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S32-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S32-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S32-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S32-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S32-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S32-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S33-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ03_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S33-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S33-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S33-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S33-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S33-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S33-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S33-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S33-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S34-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ04_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S34-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S34-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S34-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S34-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S34-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S34-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S34-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S34-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S35-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ07_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S35-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S35-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S35-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S35-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S35-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S35-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S35-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S35-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S36-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ08_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S36-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S36-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S36-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S36-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S36-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S36-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S36-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S36-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S37-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ10_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S37-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S37-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S37-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S37-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S37-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S37-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S37-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S37-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S38-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ01_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S38-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S38-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S38-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S38-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S38-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S38-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S38-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S38-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S39-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ06_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S39-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S39-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S39-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S39-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S39-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S39-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S39-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S39-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S40-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ05_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S40-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S40-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S40-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S40-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S40-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S40-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S40-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S40-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S41-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ02_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S41-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S41-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S41-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S41-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S41-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S41-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S41-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S41-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S42-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ09_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S42-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S42-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S42-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S42-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S42-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S42-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S42-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S42-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S43-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ03_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S43-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S43-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S43-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S43-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S43-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S43-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S43-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S43-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S44-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ04_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S44-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S44-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S44-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S44-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S44-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S44-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S44-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S44-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S45-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ07_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S45-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S45-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S45-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S45-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S45-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S45-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S45-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S45-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S46-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ08_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S46-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S46-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S46-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S46-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S46-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S46-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S46-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S46-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S47-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ10_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S47-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S47-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S47-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S47-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S47-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S47-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S47-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S47-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S48-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ01_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S48-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S48-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S48-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S48-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S48-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S48-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S48-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S48-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S49-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ06_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S49-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S49-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S49-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S49-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S49-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S49-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S49-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S49-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S50-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ05_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S50-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S50-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S50-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S50-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S50-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S50-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S50-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S50-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S51-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ02_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S51-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S51-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S51-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S51-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S51-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S51-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S51-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S51-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S52-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ09_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S52-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S52-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S52-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S52-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S52-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S52-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S52-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S52-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S53-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ03_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S53-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S53-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S53-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S53-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S53-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S53-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S53-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S53-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S54-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ04_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S54-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S54-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S54-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S54-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S54-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S54-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S54-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S54-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S55-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ07_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S55-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S55-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S55-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S55-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S55-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S55-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S55-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S55-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S56-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ08_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S56-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S56-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S56-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S56-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S56-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S56-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S56-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S56-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S57-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ10_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S57-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S57-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S57-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S57-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S57-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S57-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S57-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S57-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S58-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ01_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S58-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S58-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S58-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S58-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S58-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S58-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S58-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S58-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S59-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ06_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S59-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S59-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S59-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S59-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S59-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S59-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S59-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S59-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S60-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ05_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S60-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S60-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S60-assay0---nmr-spectroscopy-Acquisition-R1", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_001, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
    term_source=
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        uri=, 
        description=, 
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        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S60-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S60-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S60-assay0---nmr-spectroscopy-Acquisition-R2", executes_protocol=ProtocolNode(
        id=nmr_spectroscopy_000_000, 
        name=assay0 - nmr spectroscopy, 
        protocol_type=OntologyAnnotation(
    term=assay0 - nmr spectroscopy
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        uri=, 
        description=, 
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        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])
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generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S59-raw-spectral-data-file-R6', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S59-raw-spectral-data-file-R7', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S59-raw-spectral-data-file-R8', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R1', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R2', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R3', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R4', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R5', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R6', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R7', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R8', generated_from=[], comments=[])], samples=[], process_sequence=[isatools.model.Process(id="". name="AT0-S1-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ02_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S1-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S1-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S1-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S1-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S1-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S1-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S1-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S1-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S1-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S1-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S1-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S1-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S1-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S1-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S1-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S1-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S1-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S1-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S1-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S1-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S1-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S1-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S1-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S1-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S1-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S1-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S1-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S1-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S1-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S1-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S1-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S1-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S2-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ09_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S2-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S2-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S2-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S2-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S2-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S2-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S2-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S2-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S2-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S2-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S2-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S2-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S2-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S2-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S2-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S2-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S2-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S2-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S2-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S2-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S2-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S2-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S2-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S2-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S2-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S2-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S2-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S2-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S2-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S2-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S2-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S2-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S3-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ03_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S3-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S3-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S3-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S3-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S3-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S3-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S3-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S3-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S3-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S3-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S3-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S3-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S3-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S3-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S3-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S3-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S3-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S3-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S3-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S3-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S3-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S3-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S3-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S3-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S3-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S3-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S3-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S3-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S3-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S3-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S3-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S3-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S4-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ04_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S4-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S4-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S4-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S4-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S4-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S4-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S4-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S4-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S4-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S4-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S4-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S4-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S4-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S4-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S4-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S4-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S4-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S4-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S4-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S4-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S4-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S4-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S4-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S4-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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), 
        uri=, 
        description=, 
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        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S4-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S4-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S4-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S4-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S4-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S4-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S4-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S4-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S5-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ07_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S5-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S5-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S5-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S5-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S5-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S5-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S5-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S5-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S5-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S5-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S5-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S5-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S5-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S5-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S5-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S5-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S5-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S5-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S5-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S5-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S5-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S5-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S5-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S5-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S5-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S5-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S5-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S5-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S5-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S5-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S5-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S5-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S6-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ08_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S6-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S6-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S6-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S6-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S6-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S6-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S6-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S6-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S6-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S6-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S6-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S6-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S6-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S6-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S6-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S6-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S6-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S6-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S6-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S6-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S6-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S6-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S6-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S6-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S6-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S6-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S6-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S6-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S6-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S6-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S6-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S6-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S7-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ10_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S7-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S7-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S7-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S7-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S7-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S7-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S7-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S7-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S7-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S7-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S7-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S7-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S7-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S7-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S7-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S7-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S7-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S7-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S7-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S7-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S7-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S7-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S7-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S7-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S7-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S7-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S7-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S7-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S7-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S7-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S7-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S7-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S8-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ01_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S8-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S8-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S8-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S8-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S8-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S8-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S8-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S8-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S8-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S8-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S8-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S8-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S8-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S8-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S8-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S8-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S8-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S8-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S8-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S8-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S8-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S8-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S8-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S8-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S8-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S8-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S8-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S8-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S8-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S8-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S8-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S8-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S9-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ06_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S9-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S9-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S9-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S9-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S9-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S9-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S9-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S9-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S9-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S9-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S9-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S9-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S9-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S9-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S9-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S9-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S9-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S9-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S9-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S9-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S9-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S9-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S9-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S9-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S9-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S9-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S9-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S9-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S9-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S9-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S9-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S9-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S10-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ05_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S10-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S10-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S10-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S10-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S10-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S10-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S10-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S10-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S10-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S10-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S10-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S10-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S10-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S10-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S10-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S10-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S10-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S10-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S10-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S10-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S10-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S10-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S10-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S10-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S10-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S10-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S10-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S10-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S10-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S10-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S10-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S10-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S11-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ02_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S11-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S11-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S11-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S11-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S11-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S11-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S11-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S11-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S11-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S11-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S11-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S11-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S11-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S11-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S11-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S11-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S11-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S11-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S11-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S11-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S11-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S11-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S11-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S11-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S11-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S11-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S11-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S11-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S11-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S11-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S11-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S11-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S12-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ09_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S12-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S12-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S12-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S12-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S12-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S12-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S12-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S12-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S12-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S12-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S12-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S12-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S12-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S12-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S12-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S12-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S12-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S12-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S12-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S12-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S12-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S12-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S12-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S12-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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), 
        uri=, 
        description=, 
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        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S12-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S12-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S12-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S12-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S12-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S12-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S12-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S12-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S13-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ03_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S13-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S13-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S13-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S13-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S13-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S13-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S13-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S13-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S13-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S13-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S13-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S13-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S13-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S13-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S13-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S13-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S13-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S13-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S13-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S13-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S13-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S13-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S13-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S13-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S13-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S13-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S13-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S13-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S13-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S13-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S13-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S13-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S14-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ04_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S14-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S14-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S14-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S14-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S14-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S14-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S14-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S14-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S14-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S14-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S14-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S14-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S14-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S14-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S14-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S14-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S14-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S14-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S14-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S14-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S14-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S14-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S14-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S14-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S14-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S14-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S14-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S14-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S14-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S14-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S14-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S14-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S15-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ07_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S15-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S15-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S15-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S15-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S15-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S15-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S15-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S15-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S15-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S15-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S15-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S15-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S15-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S15-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S15-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S15-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S15-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S15-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S15-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S15-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S15-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S15-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S15-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S15-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S15-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S15-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S15-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S15-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S15-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S15-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S15-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S15-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S16-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ08_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S16-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S16-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S16-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S16-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S16-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S16-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S16-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S16-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S16-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S16-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S16-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S16-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S16-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S16-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S16-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S16-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S16-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S16-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S16-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S16-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S16-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S16-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S16-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S16-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
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        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S16-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S16-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S16-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S16-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S16-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S16-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S16-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S16-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S17-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ10_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S17-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S17-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S17-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S17-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S17-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S17-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S17-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S17-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S17-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S17-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S17-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S17-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S17-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S17-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S17-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S17-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S17-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S17-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S17-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S17-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S17-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S17-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S17-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S17-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S17-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S17-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S17-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S17-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S17-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S17-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S17-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S17-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S18-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ01_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S18-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S18-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S18-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S18-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S18-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S18-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S18-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S18-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S18-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S18-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S18-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S18-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S18-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S18-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S18-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S18-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S18-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S18-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S18-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S18-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S18-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S18-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S18-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S18-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S18-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S18-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S18-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S18-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S18-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S18-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S18-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S18-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S19-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ06_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S19-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S19-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S19-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S19-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S19-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S19-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S19-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S19-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S19-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S19-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S19-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S19-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S19-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S19-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S19-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S19-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S19-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S19-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S19-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S19-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S19-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S19-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S19-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S19-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S19-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S19-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S19-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S19-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S19-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S19-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S19-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S19-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S20-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ05_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S20-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S20-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S20-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S20-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S20-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S20-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S20-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S20-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S20-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S20-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S20-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S20-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S20-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S20-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S20-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S20-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S20-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S20-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S20-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S20-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S20-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S20-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S20-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S20-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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), 
        uri=, 
        description=, 
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        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S20-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S20-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S20-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S20-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S20-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S20-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S20-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S20-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S21-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ02_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S21-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S21-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S21-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S21-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S21-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S21-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S21-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S21-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S21-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S21-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S21-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S21-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S21-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S21-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S21-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S21-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S21-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S21-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S21-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S21-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S21-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S21-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S21-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S21-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S21-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S21-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S21-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S21-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S21-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S21-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S21-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S21-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S22-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ09_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S22-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S22-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S22-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S22-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S22-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S22-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S22-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S22-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S22-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S22-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S22-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S22-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S22-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S22-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S22-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S22-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S22-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S22-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S22-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S22-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S22-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S22-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S22-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S22-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S22-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S22-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S22-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S22-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S22-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S22-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S22-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S22-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S23-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ03_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S23-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S23-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S23-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S23-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S23-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S23-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S23-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S23-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S23-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S23-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S23-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S23-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S23-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S23-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S23-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S23-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S23-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S23-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S23-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S23-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S23-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S23-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S23-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S23-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S23-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S23-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S23-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S23-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S23-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S23-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S23-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S23-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S24-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ04_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S24-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S24-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S24-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S24-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S24-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S24-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S24-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S24-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S24-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S24-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S24-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S24-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S24-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S24-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S24-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S24-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S24-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S24-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S24-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S24-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S24-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S24-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S24-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S24-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S24-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S24-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S24-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S24-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S24-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S24-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S24-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S24-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S25-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ07_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S25-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S25-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S25-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S25-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S25-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S25-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S25-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S25-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S25-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S25-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S25-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S25-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S25-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S25-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S25-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S25-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S25-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S25-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S25-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S25-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S25-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S25-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S25-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S25-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S25-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S25-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S25-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S25-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S25-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S25-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S25-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S25-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S26-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ08_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S26-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S26-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S26-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S26-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S26-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S26-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S26-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S26-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S26-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S26-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S26-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S26-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S26-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S26-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S26-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S26-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S26-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S26-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S26-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S26-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S26-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S26-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S26-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S26-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S26-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S26-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S26-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S26-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S26-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S26-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S26-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S26-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S27-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ10_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S27-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S27-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S27-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S27-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S27-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S27-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S27-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S27-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S27-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S27-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S27-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S27-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S27-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S27-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S27-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S27-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S27-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S27-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S27-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S27-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S27-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S27-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S27-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S27-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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        uri=, 
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        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S27-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S27-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S27-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S27-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S27-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S27-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S27-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S27-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S28-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ01_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S28-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S28-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S28-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S28-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S28-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S28-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S28-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S28-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S28-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S28-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S28-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S28-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S28-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S28-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S28-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S28-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S28-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S28-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S28-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S28-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S28-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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), 
        uri=, 
        description=, 
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        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S28-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S28-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S28-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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), 
        uri=, 
        description=, 
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        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S28-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S28-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S28-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S28-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S28-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S28-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S28-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S28-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S29-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ06_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S29-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S29-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S29-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S29-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S29-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S29-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S29-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S29-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S29-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S29-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S29-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S29-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S29-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S29-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S29-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S29-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S29-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S29-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S29-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S29-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S29-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S29-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S29-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S29-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S29-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S29-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S29-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S29-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S29-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S29-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S29-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S29-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S30-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ05_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S30-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S30-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S30-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S30-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S30-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S30-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S30-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S30-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S30-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S30-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S30-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S30-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S30-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S30-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S30-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S30-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S30-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S30-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S30-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S30-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S30-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S30-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S30-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S30-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S30-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S30-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S30-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S30-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S30-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S30-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S30-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S30-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S31-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ02_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S31-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S31-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S31-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S31-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S31-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S31-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S31-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S31-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S31-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S31-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S31-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S31-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S31-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S31-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S31-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S31-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S31-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S31-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S31-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S31-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S31-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S31-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S31-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S31-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S31-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S31-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S31-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S31-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S31-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S31-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S31-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S31-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S32-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ09_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S32-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S32-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S32-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S32-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S32-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S32-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S32-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S32-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S32-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S32-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S32-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S32-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S32-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S32-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S32-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S32-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S32-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S32-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S32-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S32-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S32-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S32-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S32-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S32-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S32-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S32-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S32-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S32-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S32-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S32-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S32-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S32-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S33-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ03_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S33-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S33-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S33-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S33-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S33-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S33-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S33-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S33-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S33-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S33-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S33-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S33-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S33-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S33-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S33-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S33-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S33-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S33-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S33-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S33-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S33-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S33-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S33-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S33-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S33-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S33-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S33-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S33-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S33-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S33-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S33-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S33-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S34-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ04_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S34-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S34-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S34-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S34-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S34-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S34-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S34-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S34-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S34-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S34-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S34-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S34-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S34-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S34-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S34-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S34-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S34-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S34-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S34-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S34-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S34-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S34-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S34-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S34-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S34-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S34-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S34-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S34-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S34-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S34-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S34-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S34-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S35-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ07_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S35-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S35-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S35-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S35-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S35-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S35-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S35-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S35-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S35-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S35-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S35-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S35-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S35-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S35-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S35-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S35-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S35-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S35-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S35-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S35-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S35-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S35-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S35-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S35-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S35-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S35-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S35-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S35-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S35-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S35-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S35-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S35-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S36-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ08_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S36-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S36-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S36-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S36-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S36-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S36-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S36-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S36-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S36-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S36-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S36-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S36-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S36-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S36-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S36-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S36-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S36-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S36-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S36-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S36-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S36-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S36-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S36-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S36-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S36-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S36-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S36-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S36-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S36-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S36-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S36-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S36-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S37-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ10_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S37-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S37-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S37-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S37-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S37-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S37-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S37-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S37-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S37-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S37-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S37-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S37-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S37-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S37-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S37-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S37-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S37-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S37-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S37-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S37-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S37-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S37-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S37-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S37-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S37-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S37-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S37-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S37-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S37-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S37-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S37-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S37-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S38-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ01_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S38-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S38-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S38-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S38-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S38-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S38-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S38-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S38-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S38-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S38-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S38-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S38-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S38-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S38-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S38-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S38-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S38-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S38-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S38-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S38-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S38-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S38-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S38-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S38-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S38-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S38-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S38-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S38-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S38-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S38-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S38-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S38-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S39-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ06_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S39-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S39-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S39-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S39-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S39-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S39-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S39-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S39-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S39-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S39-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S39-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S39-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S39-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S39-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S39-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S39-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S39-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S39-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S39-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S39-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S39-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S39-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S39-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S39-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S39-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S39-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S39-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S39-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S39-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S39-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S39-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S39-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S40-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ05_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S40-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S40-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S40-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S40-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S40-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S40-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S40-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S40-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S40-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S40-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S40-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S40-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S40-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S40-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S40-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S40-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S40-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S40-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S40-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S40-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S40-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S40-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S40-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S40-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S40-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S40-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S40-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S40-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S40-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S40-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S40-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S40-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S41-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ02_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S41-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S41-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S41-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S41-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S41-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S41-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S41-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S41-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S41-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S41-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S41-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S41-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S41-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S41-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S41-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S41-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S41-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S41-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S41-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S41-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S41-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S41-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S41-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S41-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S41-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S41-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S41-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S41-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S41-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S41-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S41-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S41-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S42-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ09_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S42-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S42-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S42-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S42-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S42-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S42-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S42-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S42-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S42-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S42-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S42-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S42-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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    term_accession=
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        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S42-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S42-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S42-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S42-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S42-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S42-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S42-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S42-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S42-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S42-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S42-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S42-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S42-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S42-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S42-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S42-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S42-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S42-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S42-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S42-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S43-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ03_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S43-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S43-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S43-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S43-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S43-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S43-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S43-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S43-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S43-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S43-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S43-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S43-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S43-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S43-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S43-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S43-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S43-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S43-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S43-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S43-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S43-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S43-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S43-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S43-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S43-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S43-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S43-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S43-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S43-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S43-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S43-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S43-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S44-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ04_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S44-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S44-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S44-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S44-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S44-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S44-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S44-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S44-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S44-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S44-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S44-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S44-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S44-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S44-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S44-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S44-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S44-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S44-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S44-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S44-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S44-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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), 
        uri=, 
        description=, 
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        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S44-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S44-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S44-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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), 
        uri=, 
        description=, 
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        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S44-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S44-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S44-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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), 
        uri=, 
        description=, 
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        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S44-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S44-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S44-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S44-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S44-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S45-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ07_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S45-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S45-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S45-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S45-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S45-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S45-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S45-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S45-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S45-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S45-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S45-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S45-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S45-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S45-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S45-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S45-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S45-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S45-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S45-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S45-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S45-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S45-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S45-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S45-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S45-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S45-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S45-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S45-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S45-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S45-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S45-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S45-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S46-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ08_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S46-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S46-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S46-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S46-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S46-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S46-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S46-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S46-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S46-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S46-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S46-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S46-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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    term_accession=
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        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S46-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S46-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S46-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S46-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S46-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S46-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S46-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S46-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S46-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S46-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S46-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S46-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S46-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S46-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S46-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S46-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S46-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S46-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S46-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S46-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S47-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ10_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S47-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S47-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S47-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S47-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S47-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S47-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S47-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S47-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S47-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S47-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S47-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S47-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S47-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S47-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S47-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S47-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S47-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S47-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S47-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S47-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S47-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S47-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S47-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S47-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S47-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S47-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S47-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S47-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S47-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S47-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S47-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S47-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S48-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ01_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S48-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S48-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S48-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S48-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S48-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S48-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S48-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S48-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S48-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S48-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S48-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S48-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S48-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S48-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S48-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S48-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S48-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S48-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S48-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S48-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S48-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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), 
        uri=, 
        description=, 
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        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S48-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S48-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S48-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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), 
        uri=, 
        description=, 
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        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S48-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S48-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S48-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S48-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S48-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S48-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S48-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S48-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S49-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ06_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S49-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S49-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S49-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S49-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S49-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S49-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S49-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S49-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S49-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S49-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S49-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S49-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S49-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S49-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S49-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S49-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S49-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S49-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S49-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S49-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S49-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S49-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S49-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S49-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S49-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S49-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S49-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S49-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S49-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S49-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S49-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S49-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S50-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ05_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S50-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S50-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S50-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S50-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S50-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S50-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S50-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S50-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S50-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S50-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S50-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S50-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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    term_accession=
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        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S50-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S50-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S50-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S50-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S50-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S50-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S50-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S50-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S50-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S50-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S50-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S50-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S50-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S50-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S50-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S50-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S50-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S50-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S50-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S50-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S51-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ02_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S51-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S51-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S51-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S51-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S51-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S51-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S51-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S51-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S51-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S51-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S51-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S51-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S51-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S51-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S51-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S51-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S51-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S51-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S51-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S51-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S51-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S51-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S51-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S51-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S51-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S51-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S51-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S51-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S51-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S51-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S51-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S51-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S52-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ09_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S52-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S52-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S52-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S52-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S52-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S52-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S52-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S52-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S52-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S52-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S52-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S52-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S52-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S52-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S52-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S52-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S52-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S52-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S52-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S52-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S52-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S52-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S52-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S52-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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), 
        uri=, 
        description=, 
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        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S52-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S52-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S52-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S52-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S52-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S52-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S52-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S52-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S53-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ03_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S53-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S53-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S53-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S53-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S53-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S53-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S53-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S53-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S53-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S53-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S53-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S53-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S53-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S53-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S53-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S53-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S53-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S53-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S53-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S53-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S53-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S53-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S53-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S53-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S53-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S53-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S53-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S53-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S53-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S53-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S53-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S53-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S54-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ04_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S54-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S54-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S54-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S54-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S54-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S54-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S54-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S54-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S54-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S54-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S54-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S54-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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    term_accession=
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        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S54-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S54-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S54-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S54-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S54-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S54-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S54-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S54-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S54-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S54-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S54-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S54-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S54-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S54-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S54-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S54-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S54-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S54-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S54-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S54-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S55-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ07_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S55-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S55-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S55-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S55-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S55-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S55-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S55-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S55-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S55-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S55-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S55-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S55-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S55-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S55-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S55-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S55-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S55-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S55-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S55-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S55-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S55-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S55-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S55-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S55-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S55-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S55-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S55-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S55-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S55-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S55-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S55-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S55-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S56-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ08_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S56-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S56-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S56-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S56-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S56-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S56-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S56-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S56-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S56-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S56-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S56-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S56-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S56-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S56-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S56-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S56-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S56-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S56-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S56-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S56-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S56-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S56-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S56-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S56-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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), 
        uri=, 
        description=, 
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        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S56-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S56-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S56-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S56-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S56-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S56-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S56-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S56-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S57-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ10_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S57-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S57-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S57-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S57-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S57-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S57-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S57-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S57-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S57-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S57-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S57-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S57-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S57-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S57-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S57-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S57-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S57-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S57-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S57-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S57-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S57-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S57-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S57-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S57-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S57-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S57-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S57-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S57-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S57-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S57-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S57-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S57-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S58-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ01_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S58-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S58-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S58-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S58-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S58-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S58-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S58-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S58-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S58-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S58-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S58-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S58-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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    term_accession=
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        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S58-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S58-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S58-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S58-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S58-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S58-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S58-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S58-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S58-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S58-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S58-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S58-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S58-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S58-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S58-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S58-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S58-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S58-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S58-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S58-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S59-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ06_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S59-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S59-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S59-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S59-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S59-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S59-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S59-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S59-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S59-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S59-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S59-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S59-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S59-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S59-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S59-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S59-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S59-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S59-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S59-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S59-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S59-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S59-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S59-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S59-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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        uri=, 
        description=, 
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        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S59-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S59-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S59-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S59-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S59-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S59-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S59-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S59-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S60-assay0---extraction-Acquisition-R1", executes_protocol=ProtocolNode(
        id=extraction_000, 
        name=assay0 - extraction, 
        protocol_type=OntologyAnnotation(
    term=assay0 - extraction
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[])
        , date="None", performer="Unknown", inputs=[isatools.model.Sample(name='GRP1_SBJ05_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S60-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S60-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S60-assay0---derivatization-Acquisition-R1", executes_protocol=ProtocolNode(
        id=derivatization_000_000, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S60-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S60-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S60-assay0---mass-spectrometry-Acquisition-R1", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S60-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S60-assay0---mass-spectrometry-Acquisition-R2", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
    term_source=
    term_accession=
    comments=0 Comment objects
), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S60-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S60-assay0---mass-spectrometry-Acquisition-R3", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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        uri=, 
        description=, 
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        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S60-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S60-assay0---mass-spectrometry-Acquisition-R4", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_000, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S60-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S60-assay0---derivatization-Acquisition-R2", executes_protocol=ProtocolNode(
        id=derivatization_000_001, 
        name=assay0 - derivatization, 
        protocol_type=OntologyAnnotation(
    term=assay0 - derivatization
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), 
        uri=, 
        description=, 
        version=, 
        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.Extract(name='AT0-S60-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S60-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id="". name="AT0-S60-assay0---mass-spectrometry-Acquisition-R5", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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), 
        uri=, 
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        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S60-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S60-assay0---mass-spectrometry-Acquisition-R6", executes_protocol=ProtocolNode(
        id=mass_spectrometry_001_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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), 
        uri=, 
        description=, 
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        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S60-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S60-assay0---mass-spectrometry-Acquisition-R7", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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), 
        uri=, 
        description=, 
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        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S60-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id="". name="AT0-S60-assay0---mass-spectrometry-Acquisition-R8", executes_protocol=ProtocolNode(
        id=mass_spectrometry_000_001, 
        name=assay0 - mass spectrometry, 
        protocol_type=OntologyAnnotation(
    term=assay0 - mass spectrometry
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        uri=, 
        description=, 
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        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])
        , date="None", performer="Unknown", inputs=[isatools.model.LabeledExtract(name='AT0-S60-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R8', generated_from=[], comments=[])])], other_material=[isatools.model.Extract(name='AT0-S1-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.LabeledExtract(name='AT0-S1-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S1-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.LabeledExtract(name='AT0-S1-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S2-Extract-R1', type='Extract Name', 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isatools.model.LabeledExtract(name='AT0-S2-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S3-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.LabeledExtract(name='AT0-S3-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[]), 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characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')]), isatools.model.Sample(name='GRP1_SBJ04_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')]), isatools.model.Sample(name='GRP1_SBJ07_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')]), isatools.model.Sample(name='GRP1_SBJ08_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')]), isatools.model.Sample(name='GRP1_SBJ10_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')]), isatools.model.Sample(name='GRP1_SBJ01_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')]), isatools.model.Sample(name='GRP1_SBJ06_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')]), isatools.model.Sample(name='GRP1_SBJ05_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], process_sequence=[isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ02_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ09_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ03_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ04_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ07_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ08_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ10_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ01_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ06_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ05_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ02_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ09_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ03_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ04_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ07_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ08_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ10_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ01_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ06_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ05_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ02_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ09_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ03_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ04_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ07_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ08_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ10_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ01_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ06_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ05_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ02_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ09_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ03_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ04_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ07_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ08_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ10_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ01_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ06_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ05_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ02_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ09_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ03_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ04_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ07_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ08_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ10_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ01_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ06_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ05_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ02_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ09_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ03_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ04_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ07_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ08_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ10_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ01_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ06_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ05_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ02_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ09_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ03_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ04_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ07_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ08_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ10_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ01_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ06_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ05_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ02_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ09_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ03_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ04_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ07_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ08_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ10_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ01_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ06_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ05_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ02_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ09_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ03_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ04_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ07_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ08_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ10_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ01_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ06_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ05_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ02_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ09_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ03_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ04_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ07_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ08_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ10_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ01_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ06_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ05_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ02_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ09_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ03_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ04_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ07_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ08_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ10_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ01_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ06_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ05_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ02_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ09_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ03_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ04_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ07_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ08_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ10_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ01_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ06_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id="". name="None", executes_protocol=Protocol(
    name=sample collection
    protocol_type=sample_collection
    uri=
    version=
    parameters=2 ProtocolParameter objects
    components=0 OntologyAnnotation objects
    comments=0 Comment objects
), date="2021-12-03", performer="Unknown", inputs=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ05_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])])], other_material=[], characteristic_categories=[], comments=[], units=[])

treatment_assay = next(iter(study.assays))

treatment_assay.graph

<networkx.classes.digraph.DiGraph at 0x12ffa49a0>

[(process.name, getattr(process.prev_process, 'name', None), getattr(process.next_process, 'name', None)) for process in treatment_assay.process_sequence]

[('AT0-S1-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S1-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S1-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S1-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S1-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S1-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S2-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S2-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S2-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S2-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S2-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S2-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S3-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S3-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S3-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S3-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S3-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S3-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S4-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S4-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S4-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S4-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S4-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S4-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S5-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S5-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S5-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S5-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S5-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S5-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S6-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S6-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S6-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S6-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S6-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S6-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S7-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S7-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S7-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S7-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S7-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S7-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S8-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S8-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S8-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S8-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S8-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S8-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S9-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S9-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S9-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S9-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S9-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S9-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S10-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S10-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S10-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S10-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S10-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S10-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S11-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S11-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S11-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S11-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S11-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S11-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S12-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S12-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S12-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S12-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S12-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S12-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S13-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S13-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S13-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S13-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S13-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S13-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S14-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S14-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S14-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S14-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S14-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S14-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S15-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S15-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S15-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S15-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S15-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S15-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S16-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S16-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S16-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S16-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S16-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S16-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S17-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S17-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S17-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S17-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S17-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S17-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S18-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S18-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S18-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S18-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S18-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S18-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S19-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S19-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S19-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S19-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S19-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S19-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S20-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S20-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S20-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S20-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S20-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S20-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S21-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S21-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S21-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S21-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S21-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S21-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S22-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S22-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S22-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S22-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S22-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S22-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S23-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S23-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S23-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S23-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S23-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S23-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S24-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S24-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S24-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S24-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S24-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S24-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S25-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S25-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S25-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S25-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S25-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S25-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S26-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S26-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S26-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S26-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S26-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S26-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S27-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S27-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S27-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S27-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S27-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S27-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S28-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S28-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S28-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S28-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S28-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S28-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S29-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S29-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S29-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S29-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S29-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S29-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S30-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S30-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S30-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S30-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S30-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S30-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S31-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S31-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S31-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S31-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S31-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S31-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S32-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S32-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S32-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S32-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S32-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S32-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S33-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S33-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S33-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S33-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S33-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S33-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S34-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S34-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S34-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S34-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S34-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S34-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S35-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S35-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S35-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S35-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S35-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S35-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S36-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S36-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S36-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S36-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S36-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S36-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S37-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S37-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S37-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S37-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S37-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S37-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S38-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S38-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S38-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S38-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S38-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S38-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S39-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S39-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S39-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S39-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S39-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S39-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S40-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S40-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S40-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S40-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S40-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S40-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S41-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S41-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S41-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S41-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S41-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S41-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S42-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S42-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S42-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S42-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S42-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S42-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S43-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S43-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S43-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S43-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S43-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S43-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S44-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S44-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S44-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S44-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S44-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S44-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S45-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S45-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S45-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S45-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S45-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S45-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S46-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S46-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S46-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S46-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S46-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S46-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S47-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S47-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S47-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S47-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S47-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S47-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S48-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S48-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S48-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S48-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S48-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S48-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S49-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S49-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S49-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S49-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S49-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S49-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S50-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S50-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S50-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S50-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S50-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S50-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S51-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S51-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S51-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S51-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S51-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S51-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S52-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S52-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S52-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S52-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S52-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S52-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S53-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S53-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S53-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S53-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S53-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S53-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S54-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S54-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S54-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S54-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S54-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S54-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S55-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S55-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S55-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S55-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S55-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S55-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S56-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S56-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S56-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S56-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S56-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S56-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S57-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S57-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S57-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S57-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S57-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S57-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S58-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S58-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S58-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S58-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S58-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S58-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S59-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S59-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S59-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S59-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S59-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S59-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S60-assay0---extraction-Acquisition-R1',
  None,
  'AT0-S60-assay0---nmr-spectroscopy-Acquisition-R2'),
 ('AT0-S60-assay0---nmr-spectroscopy-Acquisition-R1',
  'AT0-S60-assay0---extraction-Acquisition-R1',
  None),
 ('AT0-S60-assay0---nmr-spectroscopy-Acquisition-R2',
  'AT0-S60-assay0---extraction-Acquisition-R1',
  None)]

a_graph = treatment_assay.graph

len(a_graph.nodes)

isa_investigation = Investigation(studies=[study])

isa_tables = dumpdf(isa_investigation)

2021-12-03 16:20:00,430 [INFO]: isatab.py(_all_end_to_end_paths:1131) >> [0]
2021-12-03 16:20:00,520 [WARNING]: isatab.py(write_study_table_files:1194) >> [2, 1, 0, 4, 3, 6, 5, 8, 7, 10, 9, 12, 11, 14, 13, 16, 15, 18, 17, 20, 19, 22, 21, 24, 23, 26, 25, 28, 27, 30, 29, 32, 31, 34, 33, 36, 35, 38, 37, 40, 39, 42, 41, 44, 43, 46, 45, 48, 47, 50, 49, 52, 51, 54, 53, 56, 55, 58, 57, 60, 59, 62, 61, 64, 63, 66, 65, 68, 67, 70, 69, 72, 71, 74, 73, 76, 75, 78, 77, 80, 79, 82, 81, 84, 83, 86, 85, 88, 87, 90, 89, 92, 91, 94, 93, 96, 95, 98, 97, 100, 99, 102, 101, 104, 103, 106, 105, 108, 107, 110, 109, 112, 111, 114, 113, 116, 115, 118, 117, 120, 119, 122, 121, 124, 123, 126, 125, 128, 127, 130, 129, 132, 131, 134, 133, 136, 135, 138, 137, 140, 139, 142, 141, 144, 143, 146, 145, 148, 147, 150, 149, 152, 151, 154, 153, 156, 155, 158, 157, 160, 159, 162, 161, 164, 163, 166, 165, 168, 167, 170, 169, 172, 171, 174, 173, 176, 175, 178, 177, 180, 179, 182, 181, 184, 183, 186, 185, 188, 187, 190, 189, 192, 191, 194, 193, 196, 195, 198, 197, 200, 199, 202, 201, 204, 203, 206, 205, 208, 207, 210, 209, 212, 211, 214, 213, 216, 215, 218, 217, 220, 219, 222, 221, 224, 223, 226, 225, 228, 227, 230, 229, 232, 231, 234, 233, 236, 235, 238, 237, 240, 239]
2021-12-03 16:20:00,523 [INFO]: isatab.py(_longest_path_and_attrs:1091) >> [[0, 2, 1], [0, 4, 3], [0, 6, 5], [0, 8, 7], [0, 10, 9], [0, 12, 11], [0, 14, 13], [0, 16, 15], [0, 18, 17], [0, 20, 19], [0, 22, 21], [0, 24, 23], [0, 26, 25], [0, 28, 27], [0, 30, 29], [0, 32, 31], [0, 34, 33], [0, 36, 35], [0, 38, 37], [0, 40, 39], [0, 42, 41], [0, 44, 43], [0, 46, 45], [0, 48, 47], [0, 50, 49], [0, 52, 51], [0, 54, 53], [0, 56, 55], [0, 58, 57], [0, 60, 59], [0, 62, 61], [0, 64, 63], [0, 66, 65], [0, 68, 67], [0, 70, 69], [0, 72, 71], [0, 74, 73], [0, 76, 75], [0, 78, 77], [0, 80, 79], [0, 82, 81], [0, 84, 83], [0, 86, 85], [0, 88, 87], [0, 90, 89], [0, 92, 91], [0, 94, 93], [0, 96, 95], [0, 98, 97], [0, 100, 99], [0, 102, 101], [0, 104, 103], [0, 106, 105], [0, 108, 107], [0, 110, 109], [0, 112, 111], [0, 114, 113], [0, 116, 115], [0, 118, 117], [0, 120, 119], [0, 122, 121], [0, 124, 123], [0, 126, 125], [0, 128, 127], [0, 130, 129], [0, 132, 131], [0, 134, 133], [0, 136, 135], [0, 138, 137], [0, 140, 139], [0, 142, 141], [0, 144, 143], [0, 146, 145], [0, 148, 147], [0, 150, 149], [0, 152, 151], [0, 154, 153], [0, 156, 155], [0, 158, 157], [0, 160, 159], [0, 162, 161], [0, 164, 163], [0, 166, 165], [0, 168, 167], [0, 170, 169], [0, 172, 171], [0, 174, 173], [0, 176, 175], [0, 178, 177], [0, 180, 179], [0, 182, 181], [0, 184, 183], [0, 186, 185], [0, 188, 187], [0, 190, 189], [0, 192, 191], [0, 194, 193], [0, 196, 195], [0, 198, 197], [0, 200, 199], [0, 202, 201], [0, 204, 203], [0, 206, 205], [0, 208, 207], [0, 210, 209], [0, 212, 211], [0, 214, 213], [0, 216, 215], [0, 218, 217], [0, 220, 219], [0, 222, 221], [0, 224, 223], [0, 226, 225], [0, 228, 227], [0, 230, 229], [0, 232, 231], [0, 234, 233], [0, 236, 235], [0, 238, 237], [0, 240, 239]]
2021-12-03 16:20:01,546 [INFO]: isatab.py(_all_end_to_end_paths:1131) >> [121, 123, 125, 127, 129, 131, 133, 135, 137, 139, 141, 143, 145, 147, 149, 151, 153, 155, 157, 159, 161, 163, 165, 167, 169, 171, 173, 175, 177, 179, 181, 183, 185, 187, 189, 191, 193, 195, 197, 199, 201, 203, 205, 207, 209, 211, 213, 215, 217, 219, 221, 223, 225, 227, 229, 231, 233, 235, 237, 239]
2021-12-03 16:20:01,550 [INFO]: isatab.py(_longest_path_and_attrs:1091) >> [[121, 241, 242, 243], [121, 241, 245, 246], [123, 248, 249, 250], [123, 248, 252, 253], [125, 255, 256, 257], [125, 255, 259, 260], [127, 262, 263, 264], [127, 262, 266, 267], [129, 269, 270, 271], [129, 269, 273, 274], [131, 276, 277, 278], [131, 276, 280, 281], [133, 283, 287, 288], [133, 283, 284, 285], [135, 290, 291, 292], [135, 290, 294, 295], [137, 297, 298, 299], [137, 297, 301, 302], [139, 304, 305, 306], [139, 304, 308, 309], [141, 311, 312, 313], [141, 311, 315, 316], [143, 318, 319, 320], [143, 318, 322, 323], [145, 325, 326, 327], [145, 325, 329, 330], [147, 332, 333, 334], [147, 332, 336, 337], [149, 339, 340, 341], [149, 339, 343, 344], [151, 346, 347, 348], [151, 346, 350, 351], [153, 353, 354, 355], [153, 353, 357, 358], [155, 360, 361, 362], [155, 360, 364, 365], [157, 367, 368, 369], [157, 367, 371, 372], [159, 374, 375, 376], [159, 374, 378, 379], [161, 381, 385, 386], [161, 381, 382, 383], [163, 388, 389, 390], [163, 388, 392, 393], [165, 395, 396, 397], [165, 395, 399, 400], [167, 402, 403, 404], [167, 402, 406, 407], [169, 409, 410, 411], [169, 409, 413, 414], [171, 416, 417, 418], [171, 416, 420, 421], [173, 423, 424, 425], [173, 423, 427, 428], [175, 430, 431, 432], [175, 430, 434, 435], [177, 437, 438, 439], [177, 437, 441, 442], [179, 444, 448, 449], [179, 444, 445, 446], [181, 451, 452, 453], [181, 451, 455, 456], [183, 458, 459, 460], [183, 458, 462, 463], [185, 465, 466, 467], [185, 465, 469, 470], [187, 472, 473, 474], [187, 472, 476, 477], [189, 479, 480, 481], [189, 479, 483, 484], [191, 486, 487, 488], [191, 486, 490, 491], [193, 493, 494, 495], [193, 493, 497, 498], [195, 500, 501, 502], [195, 500, 504, 505], [197, 507, 511, 512], [197, 507, 508, 509], [199, 514, 515, 516], [199, 514, 518, 519], [201, 521, 522, 523], [201, 521, 525, 526], [203, 528, 529, 530], [203, 528, 532, 533], [205, 535, 536, 537], [205, 535, 539, 540], [207, 542, 543, 544], [207, 542, 546, 547], [209, 549, 550, 551], [209, 549, 553, 554], [211, 556, 557, 558], [211, 556, 560, 561], [213, 563, 564, 565], [213, 563, 567, 568], [215, 570, 571, 572], [215, 570, 574, 575], [217, 577, 578, 579], [217, 577, 581, 582], [219, 584, 585, 586], [219, 584, 588, 589], [221, 591, 592, 593], [221, 591, 595, 596], [223, 598, 599, 600], [223, 598, 602, 603], [225, 605, 609, 610], [225, 605, 606, 607], [227, 612, 613, 614], [227, 612, 616, 617], [229, 619, 620, 621], [229, 619, 623, 624], [231, 626, 627, 628], [231, 626, 630, 631], [233, 633, 634, 635], [233, 633, 637, 638], [235, 640, 641, 642], [235, 640, 644, 645], [237, 647, 648, 649], [237, 647, 651, 652], [239, 654, 655, 656], [239, 654, 658, 659]]
2021-12-03 16:20:01,554 [INFO]: isatab.py(_longest_path_and_attrs:1091) >> [[121, 241, 242, 243], [121, 241, 245, 246], [123, 248, 249, 250], [123, 248, 252, 253], [125, 255, 256, 257], [125, 255, 259, 260], [127, 262, 263, 264], [127, 262, 266, 267], [129, 269, 270, 271], [129, 269, 273, 274], [131, 276, 277, 278], [131, 276, 280, 281], [133, 283, 287, 288], [133, 283, 284, 285], [135, 290, 291, 292], [135, 290, 294, 295], [137, 297, 298, 299], [137, 297, 301, 302], [139, 304, 305, 306], [139, 304, 308, 309], [141, 311, 312, 313], [141, 311, 315, 316], [143, 318, 319, 320], [143, 318, 322, 323], [145, 325, 326, 327], [145, 325, 329, 330], [147, 332, 333, 334], [147, 332, 336, 337], [149, 339, 340, 341], [149, 339, 343, 344], [151, 346, 347, 348], [151, 346, 350, 351], [153, 353, 354, 355], [153, 353, 357, 358], [155, 360, 361, 362], [155, 360, 364, 365], [157, 367, 368, 369], [157, 367, 371, 372], [159, 374, 375, 376], [159, 374, 378, 379], [161, 381, 385, 386], [161, 381, 382, 383], [163, 388, 389, 390], [163, 388, 392, 393], [165, 395, 396, 397], [165, 395, 399, 400], [167, 402, 403, 404], [167, 402, 406, 407], [169, 409, 410, 411], [169, 409, 413, 414], [171, 416, 417, 418], [171, 416, 420, 421], [173, 423, 424, 425], [173, 423, 427, 428], [175, 430, 431, 432], [175, 430, 434, 435], [177, 437, 438, 439], [177, 437, 441, 442], [179, 444, 448, 449], [179, 444, 445, 446], [181, 451, 452, 453], [181, 451, 455, 456], [183, 458, 459, 460], [183, 458, 462, 463], [185, 465, 466, 467], [185, 465, 469, 470], [187, 472, 473, 474], [187, 472, 476, 477], [189, 479, 480, 481], [189, 479, 483, 484], [191, 486, 487, 488], [191, 486, 490, 491], [193, 493, 494, 495], [193, 493, 497, 498], [195, 500, 501, 502], [195, 500, 504, 505], [197, 507, 511, 512], [197, 507, 508, 509], [199, 514, 515, 516], [199, 514, 518, 519], [201, 521, 522, 523], [201, 521, 525, 526], [203, 528, 529, 530], [203, 528, 532, 533], [205, 535, 536, 537], [205, 535, 539, 540], [207, 542, 543, 544], [207, 542, 546, 547], [209, 549, 550, 551], [209, 549, 553, 554], [211, 556, 557, 558], [211, 556, 560, 561], [213, 563, 564, 565], [213, 563, 567, 568], [215, 570, 571, 572], [215, 570, 574, 575], [217, 577, 578, 579], [217, 577, 581, 582], [219, 584, 585, 586], [219, 584, 588, 589], [221, 591, 592, 593], [221, 591, 595, 596], [223, 598, 599, 600], [223, 598, 602, 603], [225, 605, 609, 610], [225, 605, 606, 607], [227, 612, 613, 614], [227, 612, 616, 617], [229, 619, 620, 621], [229, 619, 623, 624], [231, 626, 627, 628], [231, 626, 630, 631], [233, 633, 634, 635], [233, 633, 637, 638], [235, 640, 641, 642], [235, 640, 644, 645], [237, 647, 648, 649], [237, 647, 651, 652], [239, 654, 655, 656], [239, 654, 658, 659]]

2021-12-03 16:20:05,844 [INFO]: isatab.py(_all_end_to_end_paths:1131) >> [1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 63, 65, 67, 69, 71, 73, 75, 77, 79, 81, 83, 85, 87, 89, 91, 93, 95, 97, 99, 101, 103, 105, 107, 109, 111, 113, 115, 117, 119]
2021-12-03 16:20:05,869 [INFO]: isatab.py(_longest_path_and_attrs:1091) >> [[1, 661, 662, 663, 664, 665], [1, 661, 662, 663, 664, 667], [1, 661, 662, 663, 664, 669], [1, 661, 662, 663, 664, 671], [1, 661, 673, 674, 675, 676], [1, 661, 673, 674, 675, 678], [1, 661, 673, 674, 675, 680], [1, 661, 673, 674, 675, 682], [3, 684, 696, 697, 698, 705], [3, 684, 685, 686, 687, 688], [3, 684, 685, 686, 687, 690], [3, 684, 685, 686, 687, 692], [3, 684, 685, 686, 687, 694], [3, 684, 696, 697, 698, 699], [3, 684, 696, 697, 698, 701], [3, 684, 696, 697, 698, 703], [5, 707, 708, 709, 710, 711], [5, 707, 708, 709, 710, 713], [5, 707, 708, 709, 710, 715], [5, 707, 708, 709, 710, 717], [5, 707, 719, 720, 721, 722], [5, 707, 719, 720, 721, 724], [5, 707, 719, 720, 721, 726], [5, 707, 719, 720, 721, 728], [7, 730, 731, 732, 733, 734], [7, 730, 731, 732, 733, 736], [7, 730, 731, 732, 733, 738], [7, 730, 731, 732, 733, 740], [7, 730, 742, 743, 744, 745], [7, 730, 742, 743, 744, 747], [7, 730, 742, 743, 744, 749], [7, 730, 742, 743, 744, 751], [9, 753, 765, 766, 767, 768], [9, 753, 765, 766, 767, 770], [9, 753, 765, 766, 767, 772], [9, 753, 765, 766, 767, 774], [9, 753, 754, 755, 756, 757], [9, 753, 754, 755, 756, 759], [9, 753, 754, 755, 756, 761], [9, 753, 754, 755, 756, 763], [11, 776, 777, 778, 779, 780], [11, 776, 777, 778, 779, 782], [11, 776, 777, 778, 779, 784], [11, 776, 777, 778, 779, 786], [11, 776, 788, 789, 790, 791], [11, 776, 788, 789, 790, 793], [11, 776, 788, 789, 790, 795], [11, 776, 788, 789, 790, 797], [13, 799, 800, 801, 802, 803], [13, 799, 800, 801, 802, 805], [13, 799, 800, 801, 802, 807], [13, 799, 800, 801, 802, 809], [13, 799, 811, 812, 813, 814], [13, 799, 811, 812, 813, 816], [13, 799, 811, 812, 813, 818], [13, 799, 811, 812, 813, 820], [15, 822, 823, 824, 825, 832], [15, 822, 834, 835, 836, 837], [15, 822, 834, 835, 836, 839], [15, 822, 834, 835, 836, 841], [15, 822, 834, 835, 836, 843], [15, 822, 823, 824, 825, 826], [15, 822, 823, 824, 825, 828], [15, 822, 823, 824, 825, 830], [17, 845, 846, 847, 848, 849], [17, 845, 846, 847, 848, 851], [17, 845, 846, 847, 848, 853], [17, 845, 846, 847, 848, 855], [17, 845, 857, 858, 859, 860], [17, 845, 857, 858, 859, 862], [17, 845, 857, 858, 859, 864], [17, 845, 857, 858, 859, 866], [19, 868, 869, 870, 871, 872], [19, 868, 869, 870, 871, 874], [19, 868, 869, 870, 871, 876], [19, 868, 869, 870, 871, 878], [19, 868, 880, 881, 882, 883], [19, 868, 880, 881, 882, 885], [19, 868, 880, 881, 882, 887], [19, 868, 880, 881, 882, 889], [21, 891, 892, 893, 894, 897], [21, 891, 892, 893, 894, 899], [21, 891, 892, 893, 894, 901], [21, 891, 903, 904, 905, 906], [21, 891, 903, 904, 905, 908], [21, 891, 903, 904, 905, 910], [21, 891, 903, 904, 905, 912], [21, 891, 892, 893, 894, 895], [23, 914, 915, 916, 917, 918], [23, 914, 915, 916, 917, 920], [23, 914, 915, 916, 917, 922], [23, 914, 915, 916, 917, 924], [23, 914, 926, 927, 928, 929], [23, 914, 926, 927, 928, 931], [23, 914, 926, 927, 928, 933], [23, 914, 926, 927, 928, 935], [25, 937, 938, 939, 940, 941], [25, 937, 938, 939, 940, 943], [25, 937, 938, 939, 940, 945], [25, 937, 938, 939, 940, 947], [25, 937, 949, 950, 951, 952], [25, 937, 949, 950, 951, 954], [25, 937, 949, 950, 951, 956], [25, 937, 949, 950, 951, 958], [27, 960, 961, 962, 963, 964], [27, 960, 961, 962, 963, 966], [27, 960, 961, 962, 963, 968], [27, 960, 961, 962, 963, 970], [27, 960, 972, 973, 974, 975], [27, 960, 972, 973, 974, 977], [27, 960, 972, 973, 974, 979], [27, 960, 972, 973, 974, 981], [29, 983, 984, 985, 986, 987], [29, 983, 984, 985, 986, 989], [29, 983, 984, 985, 986, 991], [29, 983, 984, 985, 986, 993], [29, 983, 995, 996, 997, 998], [29, 983, 995, 996, 997, 1000], [29, 983, 995, 996, 997, 1002], [29, 983, 995, 996, 997, 1004], [31, 1006, 1018, 1019, 1020, 1025], [31, 1006, 1018, 1019, 1020, 1027], [31, 1006, 1007, 1008, 1009, 1010], [31, 1006, 1007, 1008, 1009, 1012], [31, 1006, 1007, 1008, 1009, 1014], [31, 1006, 1007, 1008, 1009, 1016], [31, 1006, 1018, 1019, 1020, 1021], [31, 1006, 1018, 1019, 1020, 1023], [33, 1029, 1030, 1031, 1032, 1033], [33, 1029, 1030, 1031, 1032, 1035], [33, 1029, 1030, 1031, 1032, 1037], [33, 1029, 1030, 1031, 1032, 1039], [33, 1029, 1041, 1042, 1043, 1044], [33, 1029, 1041, 1042, 1043, 1046], [33, 1029, 1041, 1042, 1043, 1048], [33, 1029, 1041, 1042, 1043, 1050], [35, 1052, 1053, 1054, 1055, 1056], [35, 1052, 1053, 1054, 1055, 1058], [35, 1052, 1053, 1054, 1055, 1060], [35, 1052, 1053, 1054, 1055, 1062], [35, 1052, 1064, 1065, 1066, 1067], [35, 1052, 1064, 1065, 1066, 1069], [35, 1052, 1064, 1065, 1066, 1071], [35, 1052, 1064, 1065, 1066, 1073], [37, 1075, 1087, 1088, 1089, 1090], [37, 1075, 1087, 1088, 1089, 1092], [37, 1075, 1087, 1088, 1089, 1094], [37, 1075, 1087, 1088, 1089, 1096], [37, 1075, 1076, 1077, 1078, 1079], [37, 1075, 1076, 1077, 1078, 1081], [37, 1075, 1076, 1077, 1078, 1083], [37, 1075, 1076, 1077, 1078, 1085], [39, 1098, 1099, 1100, 1101, 1102], [39, 1098, 1099, 1100, 1101, 1104], [39, 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2021-12-03 16:20:05,881 [INFO]: isatab.py(_longest_path_and_attrs:1091) >> [[1, 661, 662, 663, 664, 665], [1, 661, 662, 663, 664, 667], [1, 661, 662, 663, 664, 669], [1, 661, 662, 663, 664, 671], [1, 661, 673, 674, 675, 676], [1, 661, 673, 674, 675, 678], [1, 661, 673, 674, 675, 680], [1, 661, 673, 674, 675, 682], [3, 684, 696, 697, 698, 705], [3, 684, 685, 686, 687, 688], [3, 684, 685, 686, 687, 690], [3, 684, 685, 686, 687, 692], [3, 684, 685, 686, 687, 694], [3, 684, 696, 697, 698, 699], [3, 684, 696, 697, 698, 701], [3, 684, 696, 697, 698, 703], [5, 707, 708, 709, 710, 711], [5, 707, 708, 709, 710, 713], [5, 707, 708, 709, 710, 715], [5, 707, 708, 709, 710, 717], [5, 707, 719, 720, 721, 722], [5, 707, 719, 720, 721, 724], [5, 707, 719, 720, 721, 726], [5, 707, 719, 720, 721, 728], [7, 730, 731, 732, 733, 734], [7, 730, 731, 732, 733, 736], [7, 730, 731, 732, 733, 738], [7, 730, 731, 732, 733, 740], [7, 730, 742, 743, 744, 745], [7, 730, 742, 743, 744, 747], [7, 730, 742, 743, 744, 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823, 824, 825, 830], [17, 845, 846, 847, 848, 849], [17, 845, 846, 847, 848, 851], [17, 845, 846, 847, 848, 853], [17, 845, 846, 847, 848, 855], [17, 845, 857, 858, 859, 860], [17, 845, 857, 858, 859, 862], [17, 845, 857, 858, 859, 864], [17, 845, 857, 858, 859, 866], [19, 868, 869, 870, 871, 872], [19, 868, 869, 870, 871, 874], [19, 868, 869, 870, 871, 876], [19, 868, 869, 870, 871, 878], [19, 868, 880, 881, 882, 883], [19, 868, 880, 881, 882, 885], [19, 868, 880, 881, 882, 887], [19, 868, 880, 881, 882, 889], [21, 891, 892, 893, 894, 897], [21, 891, 892, 893, 894, 899], [21, 891, 892, 893, 894, 901], [21, 891, 903, 904, 905, 906], [21, 891, 903, 904, 905, 908], [21, 891, 903, 904, 905, 910], [21, 891, 903, 904, 905, 912], [21, 891, 892, 893, 894, 895], [23, 914, 915, 916, 917, 918], [23, 914, 915, 916, 917, 920], [23, 914, 915, 916, 917, 922], [23, 914, 915, 916, 917, 924], [23, 914, 926, 927, 928, 929], [23, 914, 926, 927, 928, 931], [23, 914, 926, 927, 928, 933], [23, 914, 926, 927, 928, 935], [25, 937, 938, 939, 940, 941], [25, 937, 938, 939, 940, 943], [25, 937, 938, 939, 940, 945], [25, 937, 938, 939, 940, 947], [25, 937, 949, 950, 951, 952], [25, 937, 949, 950, 951, 954], [25, 937, 949, 950, 951, 956], [25, 937, 949, 950, 951, 958], [27, 960, 961, 962, 963, 964], [27, 960, 961, 962, 963, 966], [27, 960, 961, 962, 963, 968], [27, 960, 961, 962, 963, 970], [27, 960, 972, 973, 974, 975], [27, 960, 972, 973, 974, 977], [27, 960, 972, 973, 974, 979], [27, 960, 972, 973, 974, 981], [29, 983, 984, 985, 986, 987], [29, 983, 984, 985, 986, 989], [29, 983, 984, 985, 986, 991], [29, 983, 984, 985, 986, 993], [29, 983, 995, 996, 997, 998], [29, 983, 995, 996, 997, 1000], [29, 983, 995, 996, 997, 1002], [29, 983, 995, 996, 997, 1004], [31, 1006, 1018, 1019, 1020, 1025], [31, 1006, 1018, 1019, 1020, 1027], [31, 1006, 1007, 1008, 1009, 1010], [31, 1006, 1007, 1008, 1009, 1012], [31, 1006, 1007, 1008, 1009, 1014], [31, 1006, 1007, 1008, 1009, 1016], [31, 1006, 1018, 1019, 1020, 1021], [31, 1006, 1018, 1019, 1020, 1023], [33, 1029, 1030, 1031, 1032, 1033], [33, 1029, 1030, 1031, 1032, 1035], [33, 1029, 1030, 1031, 1032, 1037], [33, 1029, 1030, 1031, 1032, 1039], [33, 1029, 1041, 1042, 1043, 1044], [33, 1029, 1041, 1042, 1043, 1046], [33, 1029, 1041, 1042, 1043, 1048], [33, 1029, 1041, 1042, 1043, 1050], [35, 1052, 1053, 1054, 1055, 1056], [35, 1052, 1053, 1054, 1055, 1058], [35, 1052, 1053, 1054, 1055, 1060], [35, 1052, 1053, 1054, 1055, 1062], [35, 1052, 1064, 1065, 1066, 1067], [35, 1052, 1064, 1065, 1066, 1069], [35, 1052, 1064, 1065, 1066, 1071], [35, 1052, 1064, 1065, 1066, 1073], [37, 1075, 1087, 1088, 1089, 1090], [37, 1075, 1087, 1088, 1089, 1092], [37, 1075, 1087, 1088, 1089, 1094], [37, 1075, 1087, 1088, 1089, 1096], [37, 1075, 1076, 1077, 1078, 1079], [37, 1075, 1076, 1077, 1078, 1081], [37, 1075, 1076, 1077, 1078, 1083], [37, 1075, 1076, 1077, 1078, 1085], [39, 1098, 1099, 1100, 1101, 1102], [39, 1098, 1099, 1100, 1101, 1104], [39, 1098, 1099, 1100, 1101, 1106], [39, 1098, 1099, 1100, 1101, 1108], [39, 1098, 1110, 1111, 1112, 1113], [39, 1098, 1110, 1111, 1112, 1115], [39, 1098, 1110, 1111, 1112, 1117], [39, 1098, 1110, 1111, 1112, 1119], [41, 1121, 1122, 1123, 1124, 1125], [41, 1121, 1122, 1123, 1124, 1127], [41, 1121, 1122, 1123, 1124, 1129], [41, 1121, 1122, 1123, 1124, 1131], [41, 1121, 1133, 1134, 1135, 1136], [41, 1121, 1133, 1134, 1135, 1138], [41, 1121, 1133, 1134, 1135, 1140], [41, 1121, 1133, 1134, 1135, 1142], [43, 1144, 1145, 1146, 1147, 1152], [43, 1144, 1145, 1146, 1147, 1154], [43, 1144, 1156, 1157, 1158, 1159], [43, 1144, 1156, 1157, 1158, 1161], [43, 1144, 1156, 1157, 1158, 1163], [43, 1144, 1156, 1157, 1158, 1165], [43, 1144, 1145, 1146, 1147, 1148], [43, 1144, 1145, 1146, 1147, 1150], [45, 1167, 1168, 1169, 1170, 1171], [45, 1167, 1168, 1169, 1170, 1173], [45, 1167, 1168, 1169, 1170, 1175], [45, 1167, 1168, 1169, 1170, 1177], [45, 1167, 1179, 1180, 1181, 1182], [45, 1167, 1179, 1180, 1181, 1184], [45, 1167, 1179, 1180, 1181, 1186], [45, 1167, 1179, 1180, 1181, 1188], [47, 1190, 1191, 1192, 1193, 1194], [47, 1190, 1191, 1192, 1193, 1196], [47, 1190, 1191, 1192, 1193, 1198], [47, 1190, 1191, 1192, 1193, 1200], [47, 1190, 1202, 1203, 1204, 1205], [47, 1190, 1202, 1203, 1204, 1207], [47, 1190, 1202, 1203, 1204, 1209], [47, 1190, 1202, 1203, 1204, 1211], [49, 1213, 1214, 1215, 1216, 1217], [49, 1213, 1214, 1215, 1216, 1219], [49, 1213, 1214, 1215, 1216, 1221], [49, 1213, 1214, 1215, 1216, 1223], [49, 1213, 1225, 1226, 1227, 1228], [49, 1213, 1225, 1226, 1227, 1230], [49, 1213, 1225, 1226, 1227, 1232], [49, 1213, 1225, 1226, 1227, 1234], [51, 1236, 1237, 1238, 1239, 1240], [51, 1236, 1237, 1238, 1239, 1242], [51, 1236, 1237, 1238, 1239, 1244], [51, 1236, 1237, 1238, 1239, 1246], [51, 1236, 1248, 1249, 1250, 1251], [51, 1236, 1248, 1249, 1250, 1253], [51, 1236, 1248, 1249, 1250, 1255], [51, 1236, 1248, 1249, 1250, 1257], [53, 1259, 1271, 1272, 1273, 1280], [53, 1259, 1260, 1261, 1262, 1263], [53, 1259, 1260, 1261, 1262, 1265], [53, 1259, 1260, 1261, 1262, 1267], [53, 1259, 1260, 1261, 1262, 1269], [53, 1259, 1271, 1272, 1273, 1274], [53, 1259, 1271, 1272, 1273, 1276], [53, 1259, 1271, 1272, 1273, 1278], [55, 1282, 1283, 1284, 1285, 1286], [55, 1282, 1283, 1284, 1285, 1288], [55, 1282, 1283, 1284, 1285, 1290], [55, 1282, 1283, 1284, 1285, 1292], [55, 1282, 1294, 1295, 1296, 1297], [55, 1282, 1294, 1295, 1296, 1299], [55, 1282, 1294, 1295, 1296, 1301], [55, 1282, 1294, 1295, 1296, 1303], [57, 1305, 1306, 1307, 1308, 1309], [57, 1305, 1306, 1307, 1308, 1311], [57, 1305, 1306, 1307, 1308, 1313], [57, 1305, 1306, 1307, 1308, 1315], [57, 1305, 1317, 1318, 1319, 1320], [57, 1305, 1317, 1318, 1319, 1322], [57, 1305, 1317, 1318, 1319, 1324], [57, 1305, 1317, 1318, 1319, 1326], [59, 1328, 1340, 1341, 1342, 1345], [59, 1328, 1340, 1341, 1342, 1347], [59, 1328, 1340, 1341, 1342, 1349], [59, 1328, 1329, 1330, 1331, 1332], [59, 1328, 1329, 1330, 1331, 1334], [59, 1328, 1329, 1330, 1331, 1336], [59, 1328, 1329, 1330, 1331, 1338], [59, 1328, 1340, 1341, 1342, 1343], [61, 1351, 1352, 1353, 1354, 1355], [61, 1351, 1352, 1353, 1354, 1357], [61, 1351, 1352, 1353, 1354, 1359], [61, 1351, 1352, 1353, 1354, 1361], [61, 1351, 1363, 1364, 1365, 1366], [61, 1351, 1363, 1364, 1365, 1368], [61, 1351, 1363, 1364, 1365, 1370], [61, 1351, 1363, 1364, 1365, 1372], [63, 1374, 1375, 1376, 1377, 1378], [63, 1374, 1375, 1376, 1377, 1380], [63, 1374, 1375, 1376, 1377, 1382], [63, 1374, 1375, 1376, 1377, 1384], [63, 1374, 1386, 1387, 1388, 1389], [63, 1374, 1386, 1387, 1388, 1391], [63, 1374, 1386, 1387, 1388, 1393], [63, 1374, 1386, 1387, 1388, 1395], [65, 1397, 1409, 1410, 1411, 1412], [65, 1397, 1409, 1410, 1411, 1414], [65, 1397, 1409, 1410, 1411, 1416], [65, 1397, 1409, 1410, 1411, 1418], [65, 1397, 1398, 1399, 1400, 1401], [65, 1397, 1398, 1399, 1400, 1403], [65, 1397, 1398, 1399, 1400, 1405], [65, 1397, 1398, 1399, 1400, 1407], [67, 1420, 1421, 1422, 1423, 1424], [67, 1420, 1421, 1422, 1423, 1426], [67, 1420, 1421, 1422, 1423, 1428], [67, 1420, 1421, 1422, 1423, 1430], [67, 1420, 1432, 1433, 1434, 1435], [67, 1420, 1432, 1433, 1434, 1437], [67, 1420, 1432, 1433, 1434, 1439], [67, 1420, 1432, 1433, 1434, 1441], [69, 1443, 1444, 1445, 1446, 1447], [69, 1443, 1444, 1445, 1446, 1449], [69, 1443, 1444, 1445, 1446, 1451], [69, 1443, 1444, 1445, 1446, 1453], [69, 1443, 1455, 1456, 1457, 1458], [69, 1443, 1455, 1456, 1457, 1460], [69, 1443, 1455, 1456, 1457, 1462], [69, 1443, 1455, 1456, 1457, 1464], [71, 1466, 1467, 1468, 1469, 1472], [71, 1466, 1467, 1468, 1469, 1474], [71, 1466, 1467, 1468, 1469, 1476], [71, 1466, 1478, 1479, 1480, 1481], [71, 1466, 1478, 1479, 1480, 1483], [71, 1466, 1478, 1479, 1480, 1485], [71, 1466, 1478, 1479, 1480, 1487], [71, 1466, 1467, 1468, 1469, 1470], [73, 1489, 1490, 1491, 1492, 1493], [73, 1489, 1490, 1491, 1492, 1495], [73, 1489, 1490, 1491, 1492, 1497], [73, 1489, 1490, 1491, 1492, 1499], [73, 1489, 1501, 1502, 1503, 1504], [73, 1489, 1501, 1502, 1503, 1506], [73, 1489, 1501, 1502, 1503, 1508], [73, 1489, 1501, 1502, 1503, 1510], [75, 1512, 1513, 1514, 1515, 1516], [75, 1512, 1513, 1514, 1515, 1518], [75, 1512, 1513, 1514, 1515, 1520], [75, 1512, 1513, 1514, 1515, 1522], [75, 1512, 1524, 1525, 1526, 1527], [75, 1512, 1524, 1525, 1526, 1529], [75, 1512, 1524, 1525, 1526, 1531], [75, 1512, 1524, 1525, 1526, 1533], [77, 1535, 1536, 1537, 1538, 1539], [77, 1535, 1536, 1537, 1538, 1541], [77, 1535, 1536, 1537, 1538, 1543], [77, 1535, 1536, 1537, 1538, 1545], [77, 1535, 1547, 1548, 1549, 1550], [77, 1535, 1547, 1548, 1549, 1552], [77, 1535, 1547, 1548, 1549, 1554], [77, 1535, 1547, 1548, 1549, 1556], [79, 1558, 1559, 1560, 1561, 1562], [79, 1558, 1559, 1560, 1561, 1564], [79, 1558, 1559, 1560, 1561, 1566], [79, 1558, 1559, 1560, 1561, 1568], [79, 1558, 1570, 1571, 1572, 1573], [79, 1558, 1570, 1571, 1572, 1575], [79, 1558, 1570, 1571, 1572, 1577], [79, 1558, 1570, 1571, 1572, 1579], [81, 1581, 1593, 1594, 1595, 1600], [81, 1581, 1593, 1594, 1595, 1602], [81, 1581, 1582, 1583, 1584, 1585], [81, 1581, 1582, 1583, 1584, 1587], [81, 1581, 1582, 1583, 1584, 1589], [81, 1581, 1582, 1583, 1584, 1591], [81, 1581, 1593, 1594, 1595, 1596], [81, 1581, 1593, 1594, 1595, 1598], [83, 1604, 1605, 1606, 1607, 1608], [83, 1604, 1605, 1606, 1607, 1610], [83, 1604, 1605, 1606, 1607, 1612], [83, 1604, 1605, 1606, 1607, 1614], [83, 1604, 1616, 1617, 1618, 1619], [83, 1604, 1616, 1617, 1618, 1621], [83, 1604, 1616, 1617, 1618, 1623], [83, 1604, 1616, 1617, 1618, 1625], [85, 1627, 1628, 1629, 1630, 1631], [85, 1627, 1628, 1629, 1630, 1633], [85, 1627, 1628, 1629, 1630, 1635], [85, 1627, 1628, 1629, 1630, 1637], [85, 1627, 1639, 1640, 1641, 1642], [85, 1627, 1639, 1640, 1641, 1644], [85, 1627, 1639, 1640, 1641, 1646], [85, 1627, 1639, 1640, 1641, 1648], [87, 1650, 1662, 1663, 1664, 1665], [87, 1650, 1662, 1663, 1664, 1667], [87, 1650, 1662, 1663, 1664, 1669], [87, 1650, 1662, 1663, 1664, 1671], [87, 1650, 1651, 1652, 1653, 1654], [87, 1650, 1651, 1652, 1653, 1656], [87, 1650, 1651, 1652, 1653, 1658], [87, 1650, 1651, 1652, 1653, 1660], [89, 1673, 1674, 1675, 1676, 1677], [89, 1673, 1674, 1675, 1676, 1679], [89, 1673, 1674, 1675, 1676, 1681], [89, 1673, 1674, 1675, 1676, 1683], [89, 1673, 1685, 1686, 1687, 1688], [89, 1673, 1685, 1686, 1687, 1690], [89, 1673, 1685, 1686, 1687, 1692], [89, 1673, 1685, 1686, 1687, 1694], [91, 1696, 1697, 1698, 1699, 1700], [91, 1696, 1697, 1698, 1699, 1702], [91, 1696, 1697, 1698, 1699, 1704], [91, 1696, 1697, 1698, 1699, 1706], [91, 1696, 1708, 1709, 1710, 1711], [91, 1696, 1708, 1709, 1710, 1713], [91, 1696, 1708, 1709, 1710, 1715], [91, 1696, 1708, 1709, 1710, 1717], [93, 1719, 1720, 1721, 1722, 1729], [93, 1719, 1731, 1732, 1733, 1734], [93, 1719, 1731, 1732, 1733, 1736], [93, 1719, 1731, 1732, 1733, 1738], [93, 1719, 1731, 1732, 1733, 1740], [93, 1719, 1720, 1721, 1722, 1723], [93, 1719, 1720, 1721, 1722, 1725], [93, 1719, 1720, 1721, 1722, 1727], [95, 1742, 1743, 1744, 1745, 1746], [95, 1742, 1743, 1744, 1745, 1748], [95, 1742, 1743, 1744, 1745, 1750], [95, 1742, 1743, 1744, 1745, 1752], [95, 1742, 1754, 1755, 1756, 1757], [95, 1742, 1754, 1755, 1756, 1759], [95, 1742, 1754, 1755, 1756, 1761], [95, 1742, 1754, 1755, 1756, 1763], [97, 1765, 1766, 1767, 1768, 1769], [97, 1765, 1766, 1767, 1768, 1771], [97, 1765, 1766, 1767, 1768, 1773], [97, 1765, 1766, 1767, 1768, 1775], [97, 1765, 1777, 1778, 1779, 1780], [97, 1765, 1777, 1778, 1779, 1782], [97, 1765, 1777, 1778, 1779, 1784], [97, 1765, 1777, 1778, 1779, 1786], [99, 1788, 1789, 1790, 1791, 1792], [99, 1788, 1789, 1790, 1791, 1794], [99, 1788, 1789, 1790, 1791, 1796], [99, 1788, 1789, 1790, 1791, 1798], [99, 1788, 1800, 1801, 1802, 1803], [99, 1788, 1800, 1801, 1802, 1805], [99, 1788, 1800, 1801, 1802, 1807], [99, 1788, 1800, 1801, 1802, 1809], [101, 1811, 1812, 1813, 1814, 1815], [101, 1811, 1812, 1813, 1814, 1817], [101, 1811, 1812, 1813, 1814, 1819], [101, 1811, 1812, 1813, 1814, 1821], [101, 1811, 1823, 1824, 1825, 1826], [101, 1811, 1823, 1824, 1825, 1828], [101, 1811, 1823, 1824, 1825, 1830], [101, 1811, 1823, 1824, 1825, 1832], [103, 1834, 1835, 1836, 1837, 1838], [103, 1834, 1835, 1836, 1837, 1840], [103, 1834, 1835, 1836, 1837, 1842], [103, 1834, 1835, 1836, 1837, 1844], [103, 1834, 1846, 1847, 1848, 1849], [103, 1834, 1846, 1847, 1848, 1851], [103, 1834, 1846, 1847, 1848, 1853], [103, 1834, 1846, 1847, 1848, 1855], [105, 1857, 1858, 1859, 1860, 1861], [105, 1857, 1858, 1859, 1860, 1863], [105, 1857, 1858, 1859, 1860, 1865], [105, 1857, 1858, 1859, 1860, 1867], [105, 1857, 1869, 1870, 1871, 1872], [105, 1857, 1869, 1870, 1871, 1874], [105, 1857, 1869, 1870, 1871, 1876], [105, 1857, 1869, 1870, 1871, 1878], [107, 1880, 1881, 1882, 1883, 1884], [107, 1880, 1881, 1882, 1883, 1886], [107, 1880, 1881, 1882, 1883, 1888], [107, 1880, 1881, 1882, 1883, 1890], [107, 1880, 1892, 1893, 1894, 1895], [107, 1880, 1892, 1893, 1894, 1897], [107, 1880, 1892, 1893, 1894, 1899], [107, 1880, 1892, 1893, 1894, 1901], [109, 1903, 1915, 1916, 1917, 1920], [109, 1903, 1915, 1916, 1917, 1922], [109, 1903, 1915, 1916, 1917, 1924], [109, 1903, 1904, 1905, 1906, 1907], [109, 1903, 1904, 1905, 1906, 1909], [109, 1903, 1904, 1905, 1906, 1911], [109, 1903, 1904, 1905, 1906, 1913], [109, 1903, 1915, 1916, 1917, 1918], [111, 1926, 1927, 1928, 1929, 1930], [111, 1926, 1927, 1928, 1929, 1932], [111, 1926, 1927, 1928, 1929, 1934], [111, 1926, 1927, 1928, 1929, 1936], [111, 1926, 1938, 1939, 1940, 1941], [111, 1926, 1938, 1939, 1940, 1943], [111, 1926, 1938, 1939, 1940, 1945], [111, 1926, 1938, 1939, 1940, 1947], [113, 1949, 1950, 1951, 1952, 1953], [113, 1949, 1950, 1951, 1952, 1955], [113, 1949, 1950, 1951, 1952, 1957], [113, 1949, 1950, 1951, 1952, 1959], [113, 1949, 1961, 1962, 1963, 1964], [113, 1949, 1961, 1962, 1963, 1966], [113, 1949, 1961, 1962, 1963, 1968], [113, 1949, 1961, 1962, 1963, 1970], [115, 1972, 1984, 1985, 1986, 1987], [115, 1972, 1984, 1985, 1986, 1989], [115, 1972, 1984, 1985, 1986, 1991], [115, 1972, 1984, 1985, 1986, 1993], [115, 1972, 1973, 1974, 1975, 1976], [115, 1972, 1973, 1974, 1975, 1978], [115, 1972, 1973, 1974, 1975, 1980], [115, 1972, 1973, 1974, 1975, 1982], [117, 1995, 1996, 1997, 1998, 1999], [117, 1995, 1996, 1997, 1998, 2001], [117, 1995, 1996, 1997, 1998, 2003], [117, 1995, 1996, 1997, 1998, 2005], [117, 1995, 2007, 2008, 2009, 2010], [117, 1995, 2007, 2008, 2009, 2012], [117, 1995, 2007, 2008, 2009, 2014], [117, 1995, 2007, 2008, 2009, 2016], [119, 2018, 2019, 2020, 2021, 2022], [119, 2018, 2019, 2020, 2021, 2024], [119, 2018, 2019, 2020, 2021, 2026], [119, 2018, 2019, 2020, 2021, 2028], [119, 2018, 2030, 2031, 2032, 2033], [119, 2018, 2030, 2031, 2032, 2035], [119, 2018, 2030, 2031, 2032, 2037], [119, 2018, 2030, 2031, 2032, 2039]]

#[type(x) for x in study.assays[0].graph.nodes()]

#[(getattr(el, 'name', None), type(el))for el in treatment_assay.graph.nodes()]

from isatools.model import _build_assay_graph

gph = _build_assay_graph(treatment_assay.process_sequence)

[key for key in isa_tables.keys()]

['s_study_01.txt',
 'a_AT0_metabolite-profiling_mass-spectrometry.txt',
 'a_AT0_metabolite-profiling_nmr-spectroscopy.txt']

isa_tables['s_study_01.txt']

	Source Name	Characteristics[Study Subject]	Term Source REF	Term Accession Number	Protocol REF	Parameter Value[Sampling order]	Parameter Value[Study cell]	Date	Performer	Sample Name	Characteristics[organism part]	Comment[study step with treatment]	Factor Value[Sequence Order]	Factor Value[AGENT]	Factor Value[DURATION]	Unit	Factor Value[INTENSITY]	Unit.1
0	GRP1_SBJ05	Human	NCIT	http://purl.obolibrary.org/obo/NCIT_C14225	sample collection	001	screen	2021-12-03	Unknown	GRP1_SBJ02_screen_SMP-blood-1	blood	NO	0		100.0	day
1	GRP1_SBJ05	Human	NCIT	http://purl.obolibrary.org/obo/NCIT_C14225	sample collection	088	SINGLE TREATMENT FIRST	2021-12-03	Unknown	GRP1_SBJ01_SINGLE-TREATMENT-FIRST_SMP-heart-1	heart	YES	2	nitroglycerin	100.0	s	5.0	kg/m^3
2	GRP1_SBJ05	Human	NCIT	http://purl.obolibrary.org/obo/NCIT_C14225	sample collection	087	SINGLE TREATMENT FIRST	2021-12-03	Unknown	GRP1_SBJ10_SINGLE-TREATMENT-FIRST_SMP-heart-1	heart	YES	2	nitroglycerin	100.0	s	5.0	kg/m^3
3	GRP1_SBJ05	Human	NCIT	http://purl.obolibrary.org/obo/NCIT_C14225	sample collection	086	SINGLE TREATMENT FIRST	2021-12-03	Unknown	GRP1_SBJ08_SINGLE-TREATMENT-FIRST_SMP-heart-1	heart	YES	2	nitroglycerin	100.0	s	5.0	kg/m^3
4	GRP1_SBJ05	Human	NCIT	http://purl.obolibrary.org/obo/NCIT_C14225	sample collection	085	SINGLE TREATMENT FIRST	2021-12-03	Unknown	GRP1_SBJ07_SINGLE-TREATMENT-FIRST_SMP-heart-1	heart	YES	2	nitroglycerin	100.0	s	5.0	kg/m^3
...	...	...	...	...	...	...	...	...	...	...	...	...	...	...	...	...	...	...
115	GRP1_SBJ05	Human	NCIT	http://purl.obolibrary.org/obo/NCIT_C14225	sample collection	034	run-in	2021-12-03	Unknown	GRP1_SBJ04_run-in_SMP-blood-1	blood	NO	1		30.0	day
116	GRP1_SBJ05	Human	NCIT	http://purl.obolibrary.org/obo/NCIT_C14225	sample collection	033	run-in	2021-12-03	Unknown	GRP1_SBJ03_run-in_SMP-blood-1	blood	NO	1		30.0	day
117	GRP1_SBJ05	Human	NCIT	http://purl.obolibrary.org/obo/NCIT_C14225	sample collection	032	run-in	2021-12-03	Unknown	GRP1_SBJ09_run-in_SMP-blood-1	blood	NO	1		30.0	day
118	GRP1_SBJ05	Human	NCIT	http://purl.obolibrary.org/obo/NCIT_C14225	sample collection	119	follow-up	2021-12-03	Unknown	GRP1_SBJ06_follow-up_SMP-heart-1	heart	NO	3		1830.0	day
119	GRP1_SBJ05	Human	NCIT	http://purl.obolibrary.org/obo/NCIT_C14225	sample collection	120	follow-up	2021-12-03	Unknown	GRP1_SBJ05_follow-up_SMP-heart-1	heart	NO	3		1830.0	day

120 rows × 18 columns

isa_tables['a_AT0_metabolite-profiling_nmr-spectroscopy.txt']

	Sample Name	Comment[study step with treatment]	Protocol REF	Performer	Extract Name	Characteristics[extract type]	Protocol REF.1	Parameter Value[instrument]	Parameter Value[acquisition_mode]	Parameter Value[pulse_sequence]	Performer.1	Raw Data File
0	GRP1_SBJ01_SINGLE-TREATMENT-FIRST_SMP-blood-1	YES	assay0 - extraction	Unknown	AT0-S8-Extract-R2	supernatant	assay0 - nmr spectroscopy	Bruker AvanceII 1 GHz	1D 13C NMR	CPMG	Unknown	AT0-S8-raw_spectral_data_file-R2-
1	GRP1_SBJ01_SINGLE-TREATMENT-FIRST_SMP-blood-1	YES	assay0 - extraction	Unknown	AT0-S8-Extract-R1	pellet	assay0 - nmr spectroscopy	Bruker AvanceII 1 GHz	1D 13C NMR	CPMG	Unknown	AT0-S8-raw_spectral_data_file-R1-
2	GRP1_SBJ01_SINGLE-TREATMENT-FIRST_SMP-heart-1	YES	assay0 - extraction	Unknown	AT0-S28-Extract-R1	pellet	assay0 - nmr spectroscopy	Bruker AvanceII 1 GHz	1D 13C NMR	CPMG	Unknown	AT0-S28-raw_spectral_data_file-R1-
3	GRP1_SBJ01_SINGLE-TREATMENT-FIRST_SMP-heart-1	YES	assay0 - extraction	Unknown	AT0-S28-Extract-R2	supernatant	assay0 - nmr spectroscopy	Bruker AvanceII 1 GHz	1D 13C NMR	CPMG	Unknown	AT0-S28-raw_spectral_data_file-R2-
4	GRP1_SBJ01_SINGLE-TREATMENT-FIRST_SMP-liver-1	YES	assay0 - extraction	Unknown	AT0-S18-Extract-R2	supernatant	assay0 - nmr spectroscopy	Bruker AvanceII 1 GHz	1D 13C NMR	CPMG	Unknown	AT0-S18-raw_spectral_data_file-R2-
...	...	...	...	...	...	...	...	...	...	...	...	...
115	GRP1_SBJ10_follow-up_SMP-blood-1	NO	assay0 - extraction	Unknown	AT0-S37-Extract-R2	supernatant	assay0 - nmr spectroscopy	Bruker AvanceII 1 GHz	1D 13C NMR	CPMG	Unknown	AT0-S37-raw_spectral_data_file-R2-
116	GRP1_SBJ10_follow-up_SMP-heart-1	NO	assay0 - extraction	Unknown	AT0-S57-Extract-R1	pellet	assay0 - nmr spectroscopy	Bruker AvanceII 1 GHz	1D 13C NMR	CPMG	Unknown	AT0-S57-raw_spectral_data_file-R1-
117	GRP1_SBJ10_follow-up_SMP-heart-1	NO	assay0 - extraction	Unknown	AT0-S57-Extract-R2	supernatant	assay0 - nmr spectroscopy	Bruker AvanceII 1 GHz	1D 13C NMR	CPMG	Unknown	AT0-S57-raw_spectral_data_file-R2-
118	GRP1_SBJ10_follow-up_SMP-liver-1	NO	assay0 - extraction	Unknown	AT0-S47-Extract-R2	supernatant	assay0 - nmr spectroscopy	Bruker AvanceII 1 GHz	1D 13C NMR	CPMG	Unknown	AT0-S47-raw_spectral_data_file-R2-
119	GRP1_SBJ10_follow-up_SMP-liver-1	NO	assay0 - extraction	Unknown	AT0-S47-Extract-R1	pellet	assay0 - nmr spectroscopy	Bruker AvanceII 1 GHz	1D 13C NMR	CPMG	Unknown	AT0-S47-raw_spectral_data_file-R1-

120 rows × 12 columns

isa_tables['a_AT0_metabolite-profiling_mass-spectrometry.txt']

	Sample Name	Comment[study step with treatment]	Protocol REF	Performer	Extract Name	Characteristics[extract type]	Protocol REF.1	Parameter Value[derivatization]	Performer.1	Labeled Extract Name	Protocol REF.2	Parameter Value[instrument]	Parameter Value[injection_mode]	Parameter Value[acquisition_mode]	Performer.2	Raw Spectral Data File
0	GRP1_SBJ01_run-in_SMP-blood-1	NO	assay0 - extraction	Unknown	AT0-S38-Extract-R2	lipids	assay0 - derivatization	bis(trimethylsilyl)acetamide	Unknown	AT0-S38-LE-R2	assay0 - mass spectrometry	Agilent QTOF	GC	negative mode	Unknown	AT0-S38-raw-spectral-data-file-R6
1	GRP1_SBJ01_run-in_SMP-blood-1	NO	assay0 - extraction	Unknown	AT0-S38-Extract-R1	polar fraction	assay0 - derivatization	bis(trimethylsilyl)acetamide	Unknown	AT0-S38-LE-R1	assay0 - mass spectrometry	Agilent QTOF	GC	negative mode	Unknown	AT0-S38-raw-spectral-data-file-R4
2	GRP1_SBJ01_run-in_SMP-blood-1	NO	assay0 - extraction	Unknown	AT0-S38-Extract-R1	polar fraction	assay0 - derivatization	bis(trimethylsilyl)acetamide	Unknown	AT0-S38-LE-R1	assay0 - mass spectrometry	Agilent QTOF	GC	negative mode	Unknown	AT0-S38-raw-spectral-data-file-R3
3	GRP1_SBJ01_run-in_SMP-blood-1	NO	assay0 - extraction	Unknown	AT0-S38-Extract-R1	polar fraction	assay0 - derivatization	bis(trimethylsilyl)acetamide	Unknown	AT0-S38-LE-R1	assay0 - mass spectrometry	Agilent QTOF	GC	positive mode	Unknown	AT0-S38-raw-spectral-data-file-R2
4	GRP1_SBJ01_run-in_SMP-blood-1	NO	assay0 - extraction	Unknown	AT0-S38-Extract-R1	polar fraction	assay0 - derivatization	bis(trimethylsilyl)acetamide	Unknown	AT0-S38-LE-R1	assay0 - mass spectrometry	Agilent QTOF	GC	positive mode	Unknown	AT0-S38-raw-spectral-data-file-R1
...	...	...	...	...	...	...	...	...	...	...	...	...	...	...	...	...
475	GRP1_SBJ10_screen_SMP-liver-1	NO	assay0 - extraction	Unknown	AT0-S17-Extract-R2	lipids	assay0 - derivatization	bis(trimethylsilyl)acetamide	Unknown	AT0-S17-LE-R2	assay0 - mass spectrometry	Agilent QTOF	GC	negative mode	Unknown	AT0-S17-raw-spectral-data-file-R6
476	GRP1_SBJ10_screen_SMP-liver-1	NO	assay0 - extraction	Unknown	AT0-S17-Extract-R2	lipids	assay0 - derivatization	bis(trimethylsilyl)acetamide	Unknown	AT0-S17-LE-R2	assay0 - mass spectrometry	Agilent QTOF	GC	negative mode	Unknown	AT0-S17-raw-spectral-data-file-R5
477	GRP1_SBJ10_screen_SMP-liver-1	NO	assay0 - extraction	Unknown	AT0-S17-Extract-R1	polar fraction	assay0 - derivatization	bis(trimethylsilyl)acetamide	Unknown	AT0-S17-LE-R1	assay0 - mass spectrometry	Agilent QTOF	GC	negative mode	Unknown	AT0-S17-raw-spectral-data-file-R4
478	GRP1_SBJ10_screen_SMP-liver-1	NO	assay0 - extraction	Unknown	AT0-S17-Extract-R1	polar fraction	assay0 - derivatization	bis(trimethylsilyl)acetamide	Unknown	AT0-S17-LE-R1	assay0 - mass spectrometry	Agilent QTOF	GC	positive mode	Unknown	AT0-S17-raw-spectral-data-file-R2
479	GRP1_SBJ10_screen_SMP-liver-1	NO	assay0 - extraction	Unknown	AT0-S17-Extract-R1	polar fraction	assay0 - derivatization	bis(trimethylsilyl)acetamide	Unknown	AT0-S17-LE-R1	assay0 - mass spectrometry	Agilent QTOF	GC	negative mode	Unknown	AT0-S17-raw-spectral-data-file-R3

480 rows × 16 columns

final_dir = os.path.abspath(os.path.join('notebook-output', 'sd-test'))

7. Serialization as ISA-JSON and ISA-Tab¶

isa_j = json.dumps(isa_investigation, cls=ISAJSONEncoder, sort_keys=True, indent=4, separators=(',', ': '))
open(os.path.join(final_dir,"isa_as_json_from_dumps2.json"),"w").write(isa_j) # this call write the string 'isa_j' to the file called 'isa_as_json_from_dumps.json'

isatab.dump(isa_obj=isa_investigation, output_path=final_dir)

8. Performing syntactic validation by invoking ISA Validator¶

with open(os.path.join(final_dir,'i_investigation.txt')) as isa:
    validation_report=isatab.validate(isa)

validation_report["errors"]

Conclusion:¶

With this notebook, we have shown how to use study design information to generate a populated instance of ISA Study object and write it to file.

About this notebook¶

authors: philippe.rocca-serra@oerc.ox.ac.uk, massimiliano.izzo@oerc.ox.ac.uk
license: CC-BY 4.0
support: isatools@googlegroups.com
issue tracker: https://github.com/ISA-tools/isa-api/issues

The ISA cookbook